Artificial Sweeteners may Have Adverse Effects on the Human Body
DOI:
https://doi.org/10.54097/r5dq4236Keywords:
Artificial sweeteners; drug resistance; obesity; cancer.Abstract
With the increasing attention to people's health, the concept of healthy diet has gradually become popular among the public. Among many processed foods, artificial sweeteners have been favored by consumers all over the world because of their low calories and high sweetness. However, with the deepening of the research on artificial sweeteners, there are continuous research on artificial sweetness. The medicine is not a completely healthy food. Through rat experiments and clinical experiments, researchers from all over the world have verified that ingestion of artificial sweeteners not only promotes drug resistance mutations in human cells, but may also affect the human central nervous system, thus interfering with the normal metabolic process of the human body, eventually causing toxic damage to brain tissue and damage to the hippocampus. Xi and memory, obesity, diabetes, hypercholesterolemia and other metabolic syndromes. In addition to the above adverse effects, there are also research results that show that the intake of aspartame is related to cancer, but the research in this regard has not reached a definite conclusion, so the final result is still controversial, and further clinical trial verification results are needed. This article has sorted out the current evidence that eating artificial sweeteners may have adverse effects on the human body, hoping to provide relevant scholars and consumers with a more objective and rational new perspective, so as to consider the intake of artificial sweeteners more carefully.
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References
Global Network. WHO released evaluation results: Aspartame may cause cancer, pay attention to intake [J]. I wish you good health, 2023(8):61.
Gerasimidis K, Bryden K, Chen X, Papachristou E, Verney A, Roig M, Hansen R, Nichols B, Papadopoulou R, Parrett A. The impact of food additives, artificial sweeteners and domestic hygiene products on the human gut microbiome and its fibre fermentation capacity. Eur J Nutr. 2020 Oct;59(7):3213-3230. doi: 10.1007/s00394-019-02161-8. Epub 2019 Dec 18. PMID: 31853641; PMCID: PMC7501109.
Yu Z, Wang Y, Henderson IR, Guo J. Artificial sweeteners stimulate horizontal transfer of extracellular antibiotic resistance genes through natural transformation. ISME J. 2022 Feb;16(2):543-554. doi: 10.1038/s41396-021-01095-6. Epub 2021 Sep 1. PMID: 34465899; PMCID: PMC8776823.
Maghiari AL, Coricovac D, Pinzaru IA, Macașoi IG, Marcovici I, Simu S, Navolan D, Dehelean C. High Concentrations of Aspartame Induce Pro-Angiogenic Effects in Ovo and Cytotoxic Effects in HT-29 Human Colorectal Carcinoma Cells. Nutrients. 2020 Nov 24;12(12):3600. doi: 10.3390/nu12123600. PMID: 33255204; PMCID: PMC7760274.
Ali Rafati, Ali Noorafshan, Mahboubeh Jahangir, Leila Hosseini, Saied Karbalay-Doust,Vitamin E can improve behavioral tests impairment, cell loss, and dendrite changes in rats’ medial prefrontal cortex induced by acceptable daily dose of aspartame,Acta Histochemica,Volume 120, Issue 1,2018
U-pathi, J.; Yeh, Y.-C.; Chen, C.-W.; Owaga, E.E.; Hsieh, R.-H. Relationship between Aspartame-Induced Cerebral Cortex Injury and Oxidative Stress, Inflammation, Mitochondrial Dysfunction, and Apoptosis in Sprague Dawley Rats. Antioxidants 2024, 13, 2. https://doi.org/10.3390/antiox13010002
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metab. 2020 Mar 3;31(3):493-502.e7. doi: 10.1016/j.cmet.2020.01.014. PMID: 32130881; PMCID: PMC7784207.
Debras C, Chazelas E, Srour B, Druesne-Pecollo N, Esseddik Y, Szabo de Edelenyi F, Agaësse C, De Sa A, Lutchia R, Gigandet S, Huybrechts I, Julia C, Kesse-Guyot E, Allès B, Andreeva VA, Galan P, Hercberg S, Deschasaux-Tanguy M, Touvier M. Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. PLoS Med. 2022 Mar 24;19(3):e1003950. doi: 10.1371/journal.pmed.1003950. PMID: 35324894; PMCID: PMC8946744
Maghiari AL, Coricovac D, Pinzaru IA, Macașoi IG, Marcovici I, Simu S, Navolan D, Dehelean C. High Concentrations of Aspartame Induce Pro-Angiogenic Effects in Ovo and Cytotoxic Effects in HT-29 Human Colorectal Carcinoma Cells. Nutrients. 2020 Nov 24;12(12):3600. doi: 10.3390/nu12123600. PMID: 33255204; PMCID: PMC7760274.
Palomar-Cros A, Straif K, Romaguera D, Aragonés N, Castaño-Vinyals G, Martin V, Moreno V, Gómez-Acebo I, Guevara M, Aizpurua A, Molina-Barceló A, Jiménez-Moleón JJ, Tardón A, Contreras-Llanes M, Marcos-Gragera R, Huerta JM, Pérez-Gómez B, Espinosa A, Hernández-Segura N, Obón-Santacana M, Alonso-Molero J, Burgui R, Amiano P, Pinto-Carbó M, Olmedo-Requena R, Fernández-Tardón G, Santos-Sánchez V, Fernández de Larrea-Baz N, Fernández-Villa T, Casabonne D, Dierssen-Sotos T, Ardanaz E, Dorronsoro A, Pollán M, Kogevinas M, Lassale C. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase-control study (MCC-Spain). Int J Cancer. 2023 Sep 1;153(5):979-993. doi: 10.1002/ijc.34577. Epub 2023 Jun 16. PMID: 37323037.
Guercio BJ, Zhang S, Niedzwiecki D, Li Y, Babic A, Morales-Oyarvide V, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Ogino S, Zoltick ES, Stampfer M, Ng K, Wu K, Willett WC, Giovannucci EL, Meyerhardt JA, Fuchs CS. Associations of artificially sweetened beverage intake with disease recurrence and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance). PLoS One. 2018 Jul 19;13(7):e0199244. doi: 10.1371/journal.pone.0199244. PMID: 30024889; PMCID: PMC6053135.
Xiaoyi He, Qianyi Zhong, Kai Yan, Guoying Li, Junhua Yang,Oral exposure to an acceptable daily intake dose of aspartame induced a delayed proinflammatory cytokine response in the cerebrospinal fluid of rats,Food and Chemical Toxicology,Volume 178,2023,113931,ISSN 0278-6915
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