Traditional Chinese Medicine Decoction for Acute Pancreatitis in Elderly Patients: A Protocol for Systematic Review and Network Meta-analysis

Authors

  • Yong Wang
  • Ying Sun
  • Tengteng Chang
  • Yanhua Yin
  • Lei Li
  • Zhaoyang Hu

DOI:

https://doi.org/10.54097/ajst.v2i3.1495

Keywords:

Traditional Chinese medicine decoction, Acute pancreatitis, Elderly patients, Protocol, Network meta-analysis.

Abstract

Background Acute pancreatitis is the most common disease of the pancreas, and is a common cause of acute abdominal pain. Elderly patients with acute pancreatitis are more likely to develop complications,and they experience substantially higher mortality than the middle-aged patients. Although many studies have shown that traditional Chinese medicine are effective for the treatment of acute pancreatitis, the efficacy and safety of different traditional Chinese medicine decoctions for acute pancreatitis in elderly patients are not fully clarified. In addition, because many traditional Chinese medicine decoctions are available for the pancreatitis, the selection of an appropriate decoction has become a pressing issue. This study aimed to compare the effectiveness of different traditional Chinese medicine decoction for elderly patients with acute pancreatitis by using network meta-analysis. Methods Random clinical studies on traditional Chinese medicine decoction for acute pancreatitis will be searched using the following databases: PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wan Fang Database, VIP Database for Chinese Technical Periodicals, Medline, and Clinical Trial Register, from their inception to June 2022. Network meta-analyses will be performed to examine the efficacy of different traditional Chinese medicine decoction in the treatment of acute pancreatitis. Results This study will evaluate the effectiveness of different traditional Chinese medicine decoction in elderly patients with acute pancreatitis. Conclusion Results from this study may contribute to provide evidence for selecting an appropriate traditional Chinese medicine decoction for elderly patients with acute pancreatitis.

References

Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, Gangarosa LM, Thiny MT, Stizenberg K, Morgan DR, Ringel Y, Kim HP, DiBonaventura MD, Carroll CF, Allen JK, Cook SF, Sandler RS, Kappelman MD, Shaheen NJ. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143:1179–1187.e3.

Greenberg JA, Hsu J, Bawazeer M, Marshall J, Friedrich JO, Nathens A, Coburn N, May GR, Pearsall E, McLeod RS. Clinical practice guideline: management of acute pancreatitis. Can J Surg. 2016 Apr;59(2):128-40. doi: 10.1503/cjs.015015. PMID: 27007094; PMCID: PMC4814287.

Iannuzzi JP, King JA, Leong JH, Quan J, Windsor JW, Tanyingoh D, Coward S, Forbes N, Heitman SJ, Shaheen AA, Swain M, Buie M, Underwood FE, Kaplan GG. Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis. Gastroenterology. 2022 Jan;162(1):122-134. doi: 10.1053/j.gastro.2021.09.043. Epub 2021 Sep 25. PMID: 34571026.

Banks PA, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut.2013;62:102–111. doi:10.1136/gutjnl-2012-302779.

Hammad AY, Ditillo M, Castanon L. Pancreatitis. Surg. Clin. North Am.2018;98:895–913. doi: 10.1016/j.suc.2018.06.001.

Bálint ER, Fűr G, Kiss L, Németh DI, Soós A, Hegyi P, Szakács Z, Tinusz B, Varjú P, Vincze Á, Erőss B, Czimmer J, Szepes Z, Varga G, Rakonczay Z Jr. Assessment of the course of acute pancreatitis in the light of aetiology: a systematic review and meta-analysis. Sci Rep. 2020 Oct 21;10(1):17936. doi: 10.1038/s41598-020-74943-8.

Goyal H, Smith B, Bayer C, et al.: Differences in Severity and Outcomes Between Hypertriglyceridemia and Alcohol-Induced Pancreatitis. N Am J Med Sci. 2016;8(2):82–7. 10.4103/1947-2714.177307

Pu W, Luo G, Chen T, Jing L, Chen X. Comparative analysis of epidemiology, etiology, and outcomes between elderly and young and middle-aged acute pancreatitis patients: a retrospective, single-center study. Eur J Gastroenterol Hepatol. 2021 Oct 1;33(10):1254-1259. doi: 10.1097/MEG.0000000000001993. PMID: 33177384.

Shineng Zeng. The Clinical Observation on Acute Pancreatitis by Chaishao Chengqi Recipe and Tongxia Huoxue Recipe[D]. Guangzhou University of traditional Chinese Medicine,2017.

Yuanmei Zhang. Clinical Study of Qingyi Tongchang Decoction Retention Enema in Treating Acute Heat-type Acute Pancreatitis[D]. Hubei University of traditional Chinese Medicine,2019.

Chinese Pancreatic Surgery Association,Chinese Society of Surgery, Chinese Medical Association. Guidelines for diagnosis and treatment of acute pancreatitis in China (2021)[J]. Chinese Journal of digestive surgery, 2021,20 (07): 730-739

Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ Clin Res 2015;349: 7647.

Wang K, Jiang Z, Yu X, Shao Y, Liu H, Wu S, Kong L, Wang Z. Comparative efficacy and safety of traditional Chinese patent medicine for cognitive dysfunction in diabetic cognitive dysfunction: A protocol for systematic review and Bayesian network meta-analysis. Medicine (Baltimore). 2022 Mar 11;101(10):e28946. doi: 10.1097/MD.0000000000028946. PMID: 35451386; PMCID: PMC8913128.

Yang C, Wang T, Chen J, He J, Li Y, Chen C, Lu G, Chen W. Traditional Chinese Medicine Formulas Alleviate Acute Pancreatitis: Pharmacological Activities and Mechanisms. Pancreas. 2021 Nov-Dec 01;50(10):1348-1356. doi: 10.1097/MPA.0000000000001931. PMID: 35041332.

Wen Y, Han C, Liu T, Wang R, Cai W, Yang J, Liang G, Yao L, Shi N, Fu X, Deng L, Sutton R, Windsor JA, Hong J, Phillips AR, Du D, Huang W, Xia Q. Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation. Phytomedicine. 2020 Dec;79:153328. doi: 10.1016/j.phymed.2020.153328. Epub 2020 Sep 1. PMID: 33007730.

Sun P, Nie M. Effect and mechanism of Angelic Shaoyaosan mediated AMPK/SIRT1 positive feedback loop to promote autophagy and regulate the systemic inflammatory response in acute pancreatitis. Cell Mol Biol (Noisy-le-grand). 2021 Aug 31;67(2):101-108. doi: 10.14715/cmb/2021.67.2.15. PMID: 34817332.

Downloads

Published

1 September 2022

How to Cite

Wang, Y., Sun, Y., Chang, T., Yin, Y., Li, L., & Hu, Z. (2022). Traditional Chinese Medicine Decoction for Acute Pancreatitis in Elderly Patients: A Protocol for Systematic Review and Network Meta-analysis. Academic Journal of Science and Technology, 2(3), 74–77. https://doi.org/10.54097/ajst.v2i3.1495

Issue

Section

Articles