Research Progress of Optical Biosensing Technology for Alpha-fetoprotein Detection

Yongdong Du

doi:10.54097/tk973916

Authors

Yongdong Du

DOI:

https://doi.org/10.54097/tk973916

Abstract

Alpha-fetoprotein (AFP) is intimately associated with the incidence and progression of liver cancer and various tumors. AFP exhibits elevated concentrations in various tumors, making it a viable positive detection marker for these malignancies. Consequently, the development of precise, ultra-sensitive, and highly selective AFP detection methods is crucial for the early detection and effective monitoring of these life-threatening diseases. Optical biosensors rank among the most efficient detection techniques currently available. These biosensors possess features such as low cost, high sensitivity, real-time monitoring, and non-invasiveness, making them more suitable for AFP detection compared to other methods. This article reviews the role of this novel biosensor in the early detection of AFP, which holds significant implications for cancer diagnosis.

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References

Abdelwahab H, Tageldin O, Hasak S, et al. AFP-producing gastric carcinoma[J]. Human Pathology Reports, 2022, 28: 300640.

Liu J, Cui D, Jiang Y, et al. Selection and characterization of a novel affibody peptide and its application in a two-site ELISA for the detection of cancer biomarker alpha-fetoprotein[J]. International Journal of Biological Macromolecules, 2021, 166: 884-892.

Wang J, Liu H, Huang X, et al. Homogeneous immunoassay for the cancer marker alpha-fetoprotein using single wavelength excitation fluorescence cross-correlation spectroscopy and CdSe/ZnS quantum dots and fluorescent dyes as labels[J]. Microchimica Acta, 2016, 183: 749-755.

Mizejewski G J, Bellisario R, Beblowski D W, et al. Commercial radioimmunoassay kit for measurement of alpha-fetoprotein adapted for use with dried blood specimens from newborns[J]. Clinical chemistry, 1982, 28(5): 1207-1210.

Wang X, Zhang Q Y, Li Z J, et al. Development of high-performance magnetic chemiluminescence enzyme immunoassay for alpha-Fetoprotein (AFP) in human serum[J]. Clinica chimica acta, 2008, 393(2): 90-94.

Borisov S M, Wolfbeis O S. Optical biosensors[J]. Chemical reviews, 2008, 108(2): 423-461.

Hutter E, Fendler J H. Exploitation of localized surface plasmon resonance[J]. Advanced materials, 2004, 16(19): 1685-1706.

Wang H, Wang X, Wang J, et al. A SPR biosensor based on signal amplification using antibody-QD conjugates for quantitative determination of multiple tumor markers[J]. Scientific reports, 2016, 6(1): 33140.

Zhang B, Kahrizi M. High-Temperature Resistance Fiber Bragg Grating Temperature Sensor Fabrication[J]. IEEE Sensors Journal, 2007, 7(4):586-591.

Yang Q, Hao Y, Chen Z, et al. Rapid and sensitive detection of cardiac markers using plasmonic gold nanostar-engineered microfiber Bragg grating biosensor[J]. Sensors and Actuators B: Chemical, 2023, 393: 134248.

Zhang B, Meng H, Wang X, et al. Fe3+ doped ZnO-Ag photocatalyst for photoelectrochemical sensing platform of ultrasensitive Hg2+ detection using exonuclease III-assisted target recycling and DNA zyme-catalyzed amplification[J]. Sensors and Actuators B: Chemical, 2018, 255: 2531-2537.

Wang J, Long J, Liu Z, et al. Label-free and high-throughput biosensing of multiple tumor markers on a single light-addressable photoelectrochemical sensor[J]. Biosensors and Bioelectronics, 2017, 91: 53-59.

Kneipp J, Kneipp H, Kneipp K. SERS—a single-molecule and nanoscale tool for bioanalytics[J]. Chemical Society Reviews, 2008, 37(5): 1052-1060.

Li X, Zhang Y, Xue B, et al. A SERS nano-tag-based fiber-optic strategy for in situ immunoassay in unprocessed whole blood[J]. Biosensors and Bioelectronics, 2017, 92: 517-522.

Richter M M. Electrochemiluminescence (ecl)[J]. Chemical Reviews, 2004, 104(6): 3003-3036.

X Wang, Gao H, Qi Q, Gao C. Zhang, Anal. Chem. 90 (2018) 3013.

E Wang R, Zhang Y, Cai J, et al. Aptamer-based fluorescent biosensors[J]. Current medicinal chemistry, 2011, 18(27): 4175-4184.

Guo L, Shi Y, Liu X, et al. Enhanced fluorescence detection of proteins using ZnO nanowires integrated inside microfluidic chips[J]. Biosensors and Bioelectronics, 2018, 99: 368-374.