Current Status of Breeding of Avermectin-producing Bacteria

Manshi Ruan

doi:10.54097/fz9rz915

Authors

Manshi Ruan

DOI:

https://doi.org/10.54097/fz9rz915

Keywords:

Avilamycin; Mutagenesis; Gene Editing; Current Status of Breeding.

Abstract

Avilamycin, also known as Peomycin, is a product of ventilated fermentation of Streptomyces viridochromogene. The aim of this paper is to provide a comprehensive overview of the current status of breeding avilamycin-producing bacteria and to discuss in depth their physicochemical properties, breeding techniques, and future development directions and strategies. Modern biotechnological tools, such as gene editing and genomics analysis, were used to accelerate the breeding progress of avilamycin with a view to realizing further improvement in its yield and quality.

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References

Zhao, S., Zhang, Y., Ji, S., et al. (2008). Selection and development of high-yielding strains of avilamycin. Chinese Journal of Biochemical Drugs, (1).

Jin, L. (2006). Selection and breeding of the bacterial strain of Peomycin-producing bacteria and research on fermentation process. Tai'an: Shandong Agricultural University.

Enderlin, G., Morales, L., Jacobs, R. F., et al. (1994). Streptomycin and alternative agents for the treatment of tularemia: review of the literature. Clinical Infectious Diseases, 19(1), 42-47.

Zhou, N., Wang, J., Zhang, J., et al. (2013). Selection and identification of streptomycin-specific single-stranded DNA aptamers and the application in the detection of streptomycin in honey. Talanta, 108, 109-116.

Zhang, X., Zhang, X., Wang, L., et al. (2014). Progress of atmospheric pressure room temperature plasma biomutagenesis breeding and its application. Journal of Chemical Engineering, 65(7), 2676-2684.

Yuan, L., Wang, L., Ma, K., et al. (2011). Characteristics of hydrogen production of an Enterobacter aerogenes mutant generated by a new atmospheric and room temperature plasma (ARTP). Biochemical Engineering Journal, 55(1), 17-22.

Zhu, C., He, Y., Du, L., et al. (2007). Inference and selection of high-yielding strains of avilamycin. Journal of South China University of Technology (Natural Science Edition), 35(4), 100-105.

Gaisser, S., Trefzer, A., Stockert, S., et al. (1997). Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes T57. Journal of Bacteriology, 179(20), 6271-6278.

Weitnauer, G., Mühlenweg, A., Trefzer, A., et al. (2001). Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avilamycin biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics. Chemistry & Biology, 8(6), 569-581.

Zhu, C. H., Lu, F. P., He, Y. N., et al. (2007). Regulation of avilamycin biosynthesis in Streptomyces viridochromogenes: effects of glucose, ammonium ion, and inorganic phosphate. Applied Microbiology Biotechnology, 73(5), 1031-1038.

Butler, M. J., Bruheim, P., Jovetic, S., et al. (2002). Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans. Applied and Environmental Microbiology, 68(10), 4731-4739.