Review of Gene Therapy on Myocardial Ischemia-Reperfusion Injury Treatment

Xiao Wang

doi:10.54097/mxvpsa10

Authors

Xiao Wang

DOI:

https://doi.org/10.54097/mxvpsa10

Keywords:

Gene Therapy; Myocardial Ischemia-Reperfusion Injury; Adenovirus; Stem Cell.

Abstract

This article aims to summarize decade research which utilizing gene therapy method on myocardial ischemia-reperfusion injury. Relative articles are collected from CNKI retrieval. By analyzing and comparing the relative research articles published decade, the recent research conclusions are summarized. Methods and conclusions are compared on each upside and downside. The recent research is center on the gene transduction or stem cell transplantation. The adenovirus and adeno-associated virus are introduced into the gene transfer. The pretreatment of stem cell transplantation is also researched in recent research. All research conclusions claim that positive results are observed after treatment, including injury reduced or reversed, myocardial protect effects. Due to the complexity of mechanism in myocardial ischemia-reperfusion injury, the works may show conflicting results at the conclusion part. However, the results are roughly positive at the practical application in treatment. Still, the conclusions are limited at laboratory research on pigs and mice, and the safety evaluates are absence in some research, which confined the clinical research and further utilizing.

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References

[1] Liu, D., Xia, Z., Han, R., et al. (2020). Review and prospect on the mechanism of myocardial ischemia-reperfusion injury. Chinese Journal of Arteriosclerosis, 28(12): 3101–4101.

[2] Pajula, J., Lähteenvuo, J., Lähteenvuo, M., et al. (2022). Adenoviral VEGF-DΔN ΔC gene therapy for myocardial ischemia. Frontiers in Bioengineering and Biotechnology, 10: https://doi.org/10.3389/fbioe.2022.999226.

[3] Wang, J., Chen, Z., Dai, Q., et al. (2020). Intravenously delivered mesenchymal stem cells prevent microvascular obstruction formation after myocardial ischemia/reperfusion injury. Basic Research in Cardiology, 115: 40 https://doi.org/ 10.1007/s00395-020-0800-8.

[4] Li, Q., Guo, Y., Ou, Q., et al. (2011). Gene transfer as a strategy to achieve permanent cardioprotection II: rAAV-mediated gene therapy with heme oxygenase-1 limits infarct size 1 year later without adverse functional consequences. Basic Research in Cardiology, 106(6): 1367–1377. https://doi.org/10. 1007/ s00395-011-0208-6.

[5] Fang, X., Wang, H., Han, D., et al. (2019). Ferroptosis as a target for protection against cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America, 116(7): 2672–2680. https://doi.org/10. 1073/ pnas. 1821022116.

[6] Qin, C., Xia, X., Pei, Z., et al. (2017). Cell and gene therapy with reporter gene imaging in myocardial ischemia. In Hell J Nucl Med, 20(3): 198–204.

[7] Zhao, J., Li, X., Hu, J., et al. (2019). Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovascular Research, 115(7): 1205–1216. https://doi.org/ 10. 1093/cvr/cvz040.

[8] Yang, J., Tang, L., Zhang, F., et al. (2021). Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis. Stem Cell Research & Therapy, 12(1): https://doi. org/10.1186/s13287-021-02649-3.

[9] Wei, Z., Qiao, S., Zhao, J., et al. (2019). miRNA-181a over-expression in mesenchymal stem cell-derived exosomes influenced inflammatory response after myocardial ischemia-reperfusion injury. Life Sciences, 232: 116632. https://doi.org/ 10. 1016/j.lfs.2019.116632.

[10] Tan, T., Tu, L., Yu, Y., et al. (2024b). Mechanisms by which silencing long-stranded noncoding RNA KCNQ1OT1 alleviates myocardial ischemia/reperfusion injury (MI/RI)-induced cardiac injury via miR-377-3p/HMOX1. BMC Cardiovascular Disorders, 24:19 https://doi.org/10.1186/ s12872-023-03693-y.

[11] Wu, H. (2012). Study of Treating Chronic HeartFailure by Transplanting Bone Marrow Mesenchymal Stem Cells Transferred with HO-1 Gene.

[12] Zhou, X., Wu, X., Xu, Q., et al. (2018). Notch1 provides myocardial protection by improving mitochondrial quality control. Journal of Cellular Physiology, 234(7): 11835–11841. https://doi.org/10.1002/jcp.27892.

[13] Wang, Z., Wang, Z., Wang, T., et al. (2019) Inhibition of miR-34a-5p protected myocardial ischemia reperfusion injury-induced apoptosis and reactive oxygen species accumulation through regulation of Notch Receptor 1 signaling. Reviews in Cardiovascular Medicine, 20(3): 187. https://doi.org/10. 31083/ j.rcm.2019.03.545.

[14] Guo, P., Yi, H., Han, M., et al. (2023). Dexmedetomidine alleviates myocardial ischemia–reperfusion injury by down-regulating miR-34b-3p to activate the Jagged1/Notch signaling pathway. International Immunopharmacology, 116: 109766. https:// doi.org/10.1016/j.intimp.2023.109766.

[15] Li, M., Jiao, L., Shao, Y., Li, H., Sun, L., Yu, Q., Gong, M., Liu, D., Wang, Y., Xuan, L., Yang, X., Qu, Y., Wang, Y., Jiang, L., Han, J., Zhang, Y., & Zhang, Y. (2022). LNCRNA-ZFAS1 promotes myocardial Ischemia-Reperfusion injury through DNA Methylation-Mediated notch1 Down-Regulation in mice. JACC. Basic to Translational Science, 7(9), 880–895. https:// doi.org/10.1016/j.jacbts.2022.06.004.

[16] Xie, B., Lin, J., Chen, X., et al. (2023). CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer. Molecular Cancer, 22:151. https://doi.org/10.1186/s12943-023-01856-1.

[17] Liu, S., Li, K., Florencio, L., et al. (2021). Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Science Translational Medicine, 13(600). https://doi.org/ 10.1126/ scitranslmed. abd6892.

[18] Zhou, Y., Liang, Q., Wu, X., et al. (2023). siRNA Delivery against Myocardial Ischemia Reperfusion Injury Mediated by Reversibly Camouflaged Biomimetic Nanocomplexes. Advanced Materials, 35:2210691. https://doi.org/10. 1002/ adma. 202210691.

[19] Niu, J., Li, Y., Song, X., et al. (2021). Cardioprotective effect of echinatin against Ischemia/Reperfusion injury: involvement of Hippo/YeS-Associated protein signaling. Frontiers in Pharmacology, 11: https://doi.org/10.3389/fphar.2020.593225.

[20] Yu, H., Tang, H., Deng, C., et al. (2021). RRM2 Improves Cardiomyocyte Proliferation after Myocardial Ischemia Reperfusion Injury through the Hippo-YAP Pathway. Disease Markers, 2021: 1–10. https://doi.org/10.1155/2021/5089872.

[21] Liu, T., Ling, C., Tian, J., et al. (2022). Protective effect of shikonin in myocardial ischemia/reperfusion injury in rats by inhibition of autophagy through the Hippo pathway. Biochemical and Biophysical Research Communications, 613: 87–93. https://doi.org/10.1016/j.bbrc.2022.04.081.

[22] Zeng, W., Cao, Y., Jiang, W., et al. (2019). Knockdown of Sfrp4 attenuates apoptosis to protect against myocardial ischemia/reperfusion injury. Journal of Pharmacological Sciences, 140(1): 14–19. https://doi.org/ 10.1016/j. jphs. 2019. 04. 003.

[23] Pasha, A., Kumar, K., Heena, S. et al. (2024). Inhibition of NF-kB and COX-2 by andrographolide regulates the progression of cervical cancer by promoting PTEN expression and suppressing PI3K/AKT signalling pathway. Scientific Reports, 14:12020. https://doi.org/10.1038/s41598-024-57304-7.

[24] Bei, Y., Zhu, Y., Zhou, J., et al. (2024). Inhibition of HMBOX1 promotes cardiomyocyte survival and glucose metabolism through GCK activation in Ischemia/Reperfusion injury. Circulation. 149: https://doi.org/10. 1161/ circulationaha. 123. 067592.

[25] Qu, Z., Pang, X., Mei, Z., et al. (2024). The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury. Redox Biology, 72: 103145. https://doi.org/ 10.1016/j. redox. 2024. 103145.

[26] Voronkov, N. S., Maslov, L. N., Vyshlov, E. V., et al. (2024). Do platelets protect the heart against ischemia/reperfusion injury or exacerbate cardiac ischemia/reperfusion injury? The role of PDGF, VEGF, and PAF. Life Sciences, 347:122617. https://doi.org/10.1016/j.lfs.2024.122617.

[27] Ge, T., Ning, B., Wu, Y., et al. (2023). MicroRNA‑specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia–reperfusion injury. In Molecular and Cellular Biochemistry. Springer Science + Business Media, LLC, part of Springer Nature. https://doi.org/10.1007/s11010-023-04876-z.