Targeting Circadian Rhythm Genes: A Novel Therapeutic Strategy for Patients with Comorbid Depression, Anxiety, and Sleep Disorder

Youran Ge

doi:10.54097/drj3kc19

Authors

Youran Ge

DOI:

https://doi.org/10.54097/drj3kc19

Keywords:

Depression; Anxiety; Sleep Disorder; Rhythm Genes.

Abstract

In contemporary society, the prevalence of mental disorders is on the rise and has gradually become an increasingly prominent public health issue. Among them, depression and anxiety disorders are the most common, and they often coexist with sleep disorders. There is a complex bidirectional correlation between the two. Rhythm genes play a core role in regulating the sleep-wake cycle and disease states. Abnormal expression or polymorphism of some rhythm genes may further participate in the comorbidity mechanism of sleep disorders and mental illnesses by influencing the circadian rhythm, neurotransmitter or hormone secretion. The current intervention methods mainly include psychotherapy, drug therapy, and several rhythm regulation strategies that are still in the exploration stage. It is worth noting that both of the latter two treatment methods may alleviate related clinical symptoms by regulating the expression of rhythm genes. However, existing research still has some limitations, such as a small sample size and an unclear mechanism of action. Therefore, in the future, it is necessary to explore the mechanism of action of rhythm genes more deeply and develop precise intervention strategies to reduce the burden of such diseases on individuals and society.

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References

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