Advances in the Synthesis of Benzoazole Compounds


  • Wenjuan Li
  • Fengying Wang


Benzimidazole, Benzoxazole, Benzimidazole, Synthesis, Reaction mechanism.


Benzozole compounds are a kind of nitrogen-containing heterocyclic compounds, which are widely used in medicine and materials, and can also be used as an important intermediate to prepare high molecular compounds. In this paper, the existing synthesis methods of benzozozole compounds are summarized, according to the reaction mechanism, which lays a foundation for the establishment of a greener, more economical and more convenient synthesis method in the future.


Download data is not yet available.


Sheng C, Che X, Wang W, et al. Design and synthesis of antifungal benzoheterocyclic derivatives by scaffold hopping[J]. European journal of medicinal chemistry, 2011, 46(5): 1706-1712.

Katritzky A R, Lan X, Yang J Z, et al. Properties and synthetic utility of N-substituted benzotriazoles[J]. Chemical reviews, 1998, 98(2): 409-548.

Jacobson P. Ueber bildung von anhydrover -bindungen des orthoamidophenylmercaptans aus thioaniliden[J]. European Journal of Inorganic Chemistry, 1886, 19(1): 1067-1077.

Chen Xingquan, Zhao Tiansheng Synthesis of 2-aminobenzimidazole [J] Fine petrochemical industry, 2004 (1): 45-46.

Zhang Z H, Yin L, Wang Y M. An expeditious synthesis of benzimidazole derivatives catalyzed by Lewis acids[J]. Catalysis Communications, 2007, 8(7): 1126-1131.

Chen Y X, Qian L F, Zhang W, et al. Efficient Aerobic Oxidative Synthesis of 2‐Substituted Benzoxazoles, Benzothiazoles, and Benzimidazoles Catalyzed by 4‐Methoxy‐TEMPO[J]. Angewandte Chemie International Edition, 2008, 47(48): 9330-9333.

Zhang Zhiwei, A new method for the synthesis of benzothiazole derivatives from disulfide catalyzed by iron [D] Inner Mongolia University of Technology, 2013:14-16.

Nale D B, Bhanage B M. N-Substituted Forma -mides as C1-Sources for the Synthesis of Benzimidazole and Benzothiazole Derivatives by Using Zinc Catalyzers[J]. Synlett, 2015, 26(20): 2835-2842.

Gao X, Yu B, Zhao Y, et al. Hydrosilane-promoted cyclization of 2-aminothiophenols by CO2 to benzothia -zoles[J]. RSC Advances, 2014, 4(100): 56957-56960.

Kumbar M N, Kamble R R, Kamble A A, et al. Design and Microwave assisted synthesis of coumarin derivatives as PDE inhibitors[J]. International journal of medicinal chemistry, 2016.




How to Cite

Li, W., & Wang, F. (2023). Advances in the Synthesis of Benzoazole Compounds. Academic Journal of Science and Technology, 4(2), 5–8. Retrieved from