Response Surface Methodology in The Optimization of Natural Product Extraction and Separation Techniques
Keywords:Response surface methodology, Anthocyanin, Flavonoids, Separation optimization.
This paper focuses on the research application of response surface methodology in the optimization of natural product extraction and separation technology, and reviews the common experimental design optimization methods, the basic concepts, classification and research methods of response surface methodology, as well as the research progress in the optimization of anthocyanin and flavonoids plant extraction; analyzes the research prospects of response surface methodology, and predicts the research hotspots and directions in the light of actual practice.
Wang Conghui, Ren Na, Wei Wei, et al. New technologies for separation and purification of natural products [J]. Applied Chemistry, 2019(8):1940-1943.
Cai Zhengxiang . Research on the application of response surface method to mechanical structure optimization problems. 2019.5.
Li Li, Zhang Sai, He Qiang, et al. Application of response surface method in experimental design and optimization [J]. Laboratory Research and Exploration, 2015,34 (08): 41-45.
Zhang Yan, Li Yongzhe. Response surface methodology and its application in the field of pharmacology [J]. Journal of Jilin Institute of Chemical Technology, 2012, 29 (07): 20-26.
Qi Chaoyang, Wang Yaqi, Guo Haoran. Application of response surface methodology in the optimization of chemical production process [J]. 2017 , 10 .
He Wei, Xue Weidong, Tang Bin. Optimization of experimental design methods and data analysis [ ]. Chemical Industry Press.2012
Song Yuye, Wang Yu, Zhu Qianlin, et al. Research progress on the sources and extraction methods of anthocyanins in plants [J]. Food Research and Development, 2022, 43(16): 199-208.
Li Mingzhi, Xie Yuting, Jiang Haiwei, et al. Optimization of ultrasonic-assisted extraction process of purple potato anthocyanin by response surface methodology and its stability study [J]. Food Science and Technology, 2015 Vol. 40 No. 07.
Xiaoju Zhang, Yian Cai, Xinyue Li, et al. Optimization of anthocyanin extraction process and antioxidant properties in purple kale by response surface methodology[J]. Food Research and Development, 2019, 40 (1): 85-91
Huo Yan, Zhao Ziyi, et al. Optimization of alcohol extraction process of anthocyanin in black bean seed coat by response surface methodology[J]. Feed Res. 2020,43(03).
Mi Z, Liu Lizhen, et al. Optimization of flavonoid extraction process and antioxidant activity of Brassica juncea by response surface methodology[J]. China Seasoning. 2022,47(07)
Wu Jing. Optimization of the extraction process of total flavonoids from Lobelia camphora by response surface methodology[J]. Biochemistry.2022,8(05)
Duan Xiaohua, Luo Shijing, et al. Optimization of the extraction process of total flavonoids from Quercus fern by response surface methodology and its antioxidant activity[J]. Journal of Jiangxi Normal University (Natural Science Edition).2022,46(05).
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