Research Progress of Brain Glioma Tumor Microenvironment


  • Shusen Xing



Glioma, Microenvironment, Immune Cells


Glioma ranks among the most ubiquitous brain tumors, and the central nervous system displays unique attributes compared to other bodily organs. A physiological blood-brain barrier exists, as well as a specialized tissue environment, inextricably linked with the onset and progression of glioma. To amplify glioma treatment prospects, it is imperative to comprehend the interplay between glioma and its environmental context. This manuscript expounds upon how the glioma environment can facilitate tumor growth, providing putative clinical targets for impeding glioma development and novel avenues for treatment.


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Pinton, L., Masetto, E., Vettore, M., et al. (2019) The immune suppressive microenvironment of human gliomas depends on the accumulation of bone marrow-derived macrophages in the center of the lesion. Journal for Immuno Therapy of Cancer, 7(1).

Jiang, T., Mao, Y., Ma, W., et al. (2016) CGCG clinical practice guidelines for the management of adult diffuse gliomas. Cancer Letters, 375(2):263-273.

Abbott, N.J. (2013) Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis., 36 (3):437-449.

Iwado, E., Ichikawa, T., Kosaka, H., et al. (2012) Role of VEGF and matrix metalloproteinase-9 in peritumoral brain edema associated with supratentorial benign meningiomas. Neuropathology, 32(6):638-646.

Agarwal, S., Sane, R., Oberoi, R., et al. (2011) Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain. Expert Rev Mol Med., 13: e17.

Wang, G., Zhong, K., Wang, Z., et al. (2022) Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities. Frontiers in Immunology, 13:964898.

Zhou, C.S., Ding,P., Wang, C.Q., et al. (2013) Detection of tumor-associated macrophage phenotype in glioma and its clinical significance. China Cancer Prevtreat, 20(11):845-849.

Josephs, D.H., Bax, H.J., Karagiannis, S.N. (2015) Tumour-associated macrophage polarisation and re-education with immunotherapy. Front Biosci., 7(2):293-308.

Murray, P.J., Allen, J.E., Biswas, S.K., et al. (2014) Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity, 41(1):14-20.

Komohara, Y., Ohnishi, K., Kuratsu, J., et al. (2008) Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. The Journal of Pathology, 216(1):15-24.

Cassetta, L., Cassol, E., Poli, G. (2011) Macrophage polarization in health and disease. Scientific World Journal, 11:2391-2402.

Zhu,X., Fang,F.,Chen, Y., et al. (2023) Interaction of tumor-associated microglia/macrophages and cancer stem cells in glioma. Life Sciences, 320:121558.

Diamond, M.S., Kinder, M., Matsushita, H., et al. (2011) Type I interferon is selectively required by dendritic cells for immune rejection of tumors. Journal of Experimental Medicine, 208(10):1989-2003.

Zhou, J., Li, L., Jia, M., et al. (2023) Dendritic cell vaccines improve the glioma microenvironment: Influence, challenges, and future directions. Cancer Medicine, 12(6):7207-7221.

Wen, P.Y., Reardon, D.A., Armstrong, T.S., et al. (2019) A randomized double-blind placebo-controlled phase II trial of dendritic cell vaccine ICT-107 in newly diagnosed patients with glioblastoma. Clinical Cancer Research, 25(19):5799-5807.

Rahbar, A., Cederarv, M., Wolmer-Solberg, N., et al. (2016) Enhanced neutrophil activity is associated with shorter time to tumor progression in glioblastoma patients. Oncoimmunology, 5(2): e1075693.

Liang, J., Piao, Y., Holmes, L., et al. (2014) Neutrophils promote the malignant glioma phenotype through S100A4. Clinical Cancer Research, 20(1):187-198.

Hor, W., Huang, W., Lin, Y., et al. (2003) Cross-talk between tumor cells and neutrophils through the Fas (APO-1, CD95)/FasL system: human glioma cells enhance cell viability and stimulate cytokine production in neutrophils. J Leukoc Biol., 73(3):363-368.

Yee, P., Wei, Y., Kim, S., et al. (2020) Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression. Nature Communications, 11(1).

Prame, K.K., Nicholls, A.J., Wong, C. (2018) Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease. Cell Tissue Res., 371(3):551-565.







How to Cite

Xing, S. (2023). Research Progress of Brain Glioma Tumor Microenvironment. International Journal of Biology and Life Sciences, 4(3), 22-24.