The Current Research Status of ICU-Acquired Muscle Weakness
DOI:
https://doi.org/10.54097/vsssec95Keywords:
ICU-acquired weakness, Pathophysiology, Diagnosis, Treatment.Abstract
ICU-acquired weakness is the most common neuromuscular injury in critically ill patients and an important issue that affects their long-term quality of life. Although ICU-acquired weakness has received increasing attention in recent years, there is still no consensus on its pathophysiological mechanisms, and there are knowledge gaps in identifying high-risk patients and subsequent treatment. This article summarizes the research on ICU-acquired weakness in terms of pathophysiological mechanisms, diagnostic methods, and treatment through a literature review.
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Vanhorebeek I, Latronico N, Van den Berghe G. ICU-acquired weakness[J]. Intensive Care Medicine, 2020, 46(4): 637-653.
Tortuyaux R, Davion J B, Jourdain M. Intensive care unit-acquired weakness: Questions the clinician should ask[J]. Revue Neurologique, 2022, 178(1): 84-92.
Inoue S, Hatakeyama J, Kondo Y, et al Post-intensive care syndrome: its pathophysiology, prevention, and future directions[J]. Acute Medicine & Surgery, 2019, 6(3): 233-246.
Jolley S E, Bunnell A E, Hough C L. ICU-Acquired Weakness[J]. Chest, 2016, 150(5): 1129-1140.
Hermans G, Van den Berghe G. Clinical review: intensive care unit acquired weakness[J]. Critical Care (London, England), 2015, 19(1): 274.
Connolly B, Salisbury L, O’Neill B, et al Exercise rehabilitation following intensive care unit discharge for recovery from critical illness[J]. The Cochrane Database of Systematic Reviews, 2015, 2015(6): CD008632.
de Jonghe B, Lacherade J C, Sharshar T, et al Intensive care unit-acquired weakness: risk factors and prevention[J]. Critical Care Medicine, 2009, 37(10 Suppl): S309-315.
Bagshaw S M, Stelfox H T, McDermid R C, et al Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study[J]. CMAJ: Canadian Medical Association Journal, 2014, 186(2): E95-E102.
Bagshaw M, Majumdar S R, Rolfson D B, et al A prospective multicenter cohort study of frailty in younger critically ill patients[J]. Critical Care, 2016, 20: 175.
Agustí A, Antó J M, Auffray C, et al Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014[J]. American Journal of Respiratory and Critical Care Medicine, 2015, 191(4): 391-401.
Yang T, Li Z, Jiang L, et al Risk factors for intensive care unit-acquired weakness: A systematic review and meta-analysis[J]. Acta Neurologica Scandinavica, 2018, 138(2): 104-114.
Latronico N, Bolton C F. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis[J]. The Lancet. Neurology, 2011, 10(10): 931-941.
Schweickert W D, Hall J. ICU-acquired weakness[J]. Chest, 2007, 131(5): 1541-1549.
Puthucheary Z A, Rawal J, McPhail M, et al Acute skeletal muscle wasting in critical illness[J]. JAMA, 2013, 310(15): 1591-1600.
Druml W, Heinzel G, Kleinberger G. Amino acid kinetics in patients with sepsis[J]. The American Journal of Clinical Nutrition, 2001, 73(5): 908-913.
Batt J, Herridge M, Dos Santos C. Mechanism of ICU-acquired weakness: skeletal muscle loss in critical illness[J]. Intensive Care Medicine, 2017, 43(12): 1844-1846.
Derde S, Hermans G, Derese I, et al Muscle atrophy and preferential loss of myosin in prolonged critically ill patients[J]. Critical Care Medicine, 2012, 40(1): 79-89.
Vanhorebeek I, Gunst J, Derde S, et al Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients[J]. The Journal of Clinical Endocrinology and Metabolism, 2011, 96(4): E633-645.
Friedrich O, Reid M B, Van den Berghe G, et al The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill[J]. Physiological Reviews, 2015, 95(3): 1025-1109.
Latronico N, Friedrich O. Electrophysiological investigations of peripheral nerves and muscles: a method for looking at cell dysfunction in the critically ill patients[J]. Critical Care (London, England), 2019, 23(1): 33.
Thiessen S E, Derde S, Derese I, et al Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition[J]. American Journal of Respiratory and Critical Care Medicine, 2017, 196(9): 1131-1143.
Stevens R D, Marshall S A, Cornblath D R, et al A framework for diagnosing and classifying intensive care unit-acquired weakness[J]. Critical Care Medicine, 2009, 37(10 Suppl): S299-308.
Casaer M P, Mesotten D, Hermans G, et al Early versus late parenteral nutrition in critically ill adults[J]. The New England Journal of Medicine, 2011, 365(6): 506-517.
Moss M, Yang M, Macht M, et al Screening for critical illness polyneuromyopathy with single nerve conduction studies[J]. Intensive Care Medicine, 2014, 40(5): 683-690.
Latronico N, Nattino G, Guarneri B, et al Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study[J]. F1000Research, 2014, 3: 127.
Wieske L, Verhamme C, Witteveen E, et al Feasibility and diagnostic accuracy of early electrophysiological recordings for ICU-acquired weakness: an observational cohort study[J]. Neurocritical Care, 2015, 22(3): 385-394.
Formenti P, Umbrello M, Coppola S, et al Clinical review: peripheral muscular ultrasound in the ICU[J]. Annals of Intensive Care, 2019, 9(1): 57.
Puthucheary Z A, Phadke R, Rawal J, et al Qualitative Ultrasound in Acute Critical Illness Muscle Wasting[J]. Critical Care Medicine, 2015, 43(8): 1603-1611.
Joskova V, Patkova A, Havel E, et al Critical evaluation of muscle mass loss as a prognostic marker of morbidity in critically ill patients and methods for its determination[J]. Journal of Rehabilitation Medicine, 2018, 50(8): 696-704.
Roberson A R, Starkweather A, Grossman C, et al Influence of muscle strength on early mobility in critically ill adult patients: Systematic literature review[J]. Heart & Lung: The Journal of Critical Care, 2018, 47(1): 1-9.
Dres M, Goligher E C, Heunks L M A, etc.. Critical illness-associated diaphragm weakness[J]. Intensive Care Medicine, 2017, 43(10): 1441-1452.
Qian Z, Yang M, Li L, et al Ultrasound assessment of diaphragmatic dysfunction as a predictor of weaning outcome from mechanical ventilation: a systematic review and meta-analysis[J]. BMJ open, 2018, 8(9): e021189.
Van den Berghe G, Schoonheydt K, Becx P, et al Insulin therapy protects the central and peripheral nervous system of intensive care patients[J]. Neurology, 2005, 64(8): 1348-1353.
Hermans G, Wilmer A, Meersseman W, et al Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit[J]. American Journal of Respiratory and Critical Care Medicine, 2007, 175(5): 480-489.
Rosa D, Negro A, Marcomini I, et al The Effects of Early Mobilization on Acquired Weakness in Intensive Care Units: A Literature Review[J]. Dimensions of critical care nursing: DCCN, 2023, 42(3): 146-152.
Tipping C J, Harrold M, Holland A, et al The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review[J]. Intensive Care Medicine, 2017, 43(2): 171-183.
Maffiuletti N A. Physiological and methodological considerations for the use of neuromuscular electrical stimulation[J]. European Journal of Applied Physiology, 2010, 110(2): 223-234.
Roig M, Reid W D. Electrical stimulation and peripheral muscle function in COPD: a systematic review[J]. Respiratory Medicine, 2009, 103(4): 485-495.
Liu M, Luo J, Zhou J, et al Intervention effect of neuromuscular electrical stimulation on ICU acquired weakness: A meta-analysis[J]. International Journal of Nursing Sciences, 2020, 7(2): 228-237.
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