Pathogenesis and Treatment Strategy of Intracranial Aneurysm


  • Gang Li



Intracranial Aneurysm, Pathogenesis, Subarachnoid Hemorrhage, Diagnosis


Intracranial aneurysm (IA) is a common cerebrovascular disease. Rupture of intracranial aneurysm can lead to subarachnoid hemorrhage, which is characterized by high mortality and poor prognosis. Once onset, the disease develops rapidly, seriously threatening people's life and health. Because intracranial aneurysms start insidiously and don't have corresponding clinical symptoms until they rupture, many patients miss the best opportunity for treatment. Even if you visit the medical center in time, there will be corresponding complications during the treatment. In recent years, with the continuous improvement of molecular biotechnology, the diagnosis and treatment of intracranial aneurysms have made great progress. This article reviews the recent progress in diagnosis, pathogenesis and postoperative treatment of intracranial aneurysms.


Download data is not yet available.


Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2016 Dec;12(12):699-713. doi: 10.1038/ nrneurol. 2016.150. Epub 2016 Nov 3. Erratum in: Nat Rev Neurol. 2017 Feb 1;13(2):126. doi: 10.1038/nrneurol.2017.14. PMID: 27808 265.

Khan D, Cornelius JF, Muhammad S. The Role of NF-κB in Intracranial Aneurysm Pathogenesis: A Systematic Review. Int J Mol Sci. 2023;24(18):14218. Published 2023 Sep 18. doi: 10. 3390/ ijms241814218.

Zhang X, Ares WJ, Taussky P, Ducruet AF, Grandhi R. Role of matrix metalloproteinases in the pathogenesis of intracranial aneurysms. Neurosurg Focus. 2019;47(1):E4. doi:10.3171/ 2019. 4. FOCUS19214.

Yi Liu, Peng Li, Xiao Hu, Yu Hu, Hao-Gen Sun, Wei-Chao Ma, Fei Qiao, Min He, Chao You. Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population[J]. Journal of International Medical Research, 2013, 41 (4): 1079-1087.

Chen Zhixing, Ma Junpeng, Cen Ying, Liu Yi, You Chao. The angiotensin converting enzyme insertion/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies. Neurol India. 2013;61(3):293-299. doi:10.4103/0028-3886.115071.

Chen Xiaodan, Liu Yun, Tong Huazhang, Dong Yonghai, Ma Dongyang, Xu Lei, Yang Cheng. Meta-analysis of computed tomography angiography versus magnetic resonance angiography for intracranial aneurysm.[J]. Medicine, 2018, 97 (20): e10771. doi:10.1097/MD.0000000000010771.

BRACARD S, BARBIER C, DERELLE A L, et al. Endovascular treatment of aneurisms: Pre, intra and post operative management [J]. European Journal of Radiology, 2013, 82(10): 1633-1637.

D'Souza S. Aneurysmal Subarachnoid Hemorrhage. J Neurosurg Anesthesiol. 2015;27(3):222-240.

Lindgren A, Vergouwen MD, van der Schaaf I, et al. Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2018;8(8):CD003085. doi:10.1002/ 1465 1858.CD003085.pub3.

MATSUKAWA H, KAMIYAMA H, MIYAZAKI T, et al. Analysis for risk factors of 12-month neurological worsening in patients with surgically treated small-to-moderate size unruptured intracranial aneurysms [J]. Journal of Clinical Neuroscience, 2018, 58: 160-164.

HWANG G, JUNG C, PARK S Q, et al. Thromboembolic Complications of Elective Coil Embolization of Unruptured Aneurysms [J]. Neurosurgery, 2010, 67(3): 743-748.

WILSON T J, PANDEY A S, STETLER W R, et al. Dual antiplatelet therapy plus postoperative heparin and dextran is safe and effective for reducing risk of embolic stroke during aneurysm coiling [J]. Acta Neurochirurgica, 2014, 156(5): 855-859.

OHTA T, MURAO K, MIYAKE K, et al. Risk Factors for Early Hemorrhagic Complications after Endovascular Coiling of Ruptured Intracranial Aneurysms [J]. American Journal of Neuroradiology, 2014, 35(11): 2136-2139.

RYU C W, PARK S, SHIN H S, et al. Complications in Stent-Assisted Endovascular Therapy of Ruptured Intracranial Aneurysms and Relevance to Antiplatelet Administration: A Systematic Review [J]. American Journal of Neuroradiology, 2015, 36(9): 1682-1688.

KIM S-T, BAEK J W, LEE W H, et al. Causes of early rebleeding after coil embolization of ruptured cerebral aneurysms [J]. Clinical Neurology and Neurosurgery, 2018, 174: 108-116.

Zhao Long, Lin Ping, Zhang Yi, Huang XingYuan, Li HangYang, Xia MingKai, Huang Xi, Li Zheng, Zhou LiangXue, Tang XiaoPing. Effect of antiplatelet treatment on aneurysmal subarachnoid hemorrhage patients after endovascular treatment: a systematic review with meta-analysis.[J]. Neurosurgical review, 2022, 45 (6): 3523-3536.

NARATA A P, AMELOT A, BIBI R, et al. Dual Antiplatelet Therapy Combining Aspirin and Ticagrelor for Intracranial Stenting Procedures: A Retrospective Single Center Study of 154 Consecutive Patients With Unruptured Aneurysms [J]. Neurosurgery, 2019, 84(1): 77-83.

LUKITO P P, LIE H, HELSA K, et al. Heparin in the treatment of aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis [J]. Neurosurgical Focus, 2022, 52(3).

BRINJIKJI W, MORALES-VALERO S F, MURAD M H, et al. Rescue Treatment of Thromboembolic Complications during Endovascular Treatment of Cerebral Aneurysms: A Meta-Analysis [J]. American Journal of Neuroradiology, 2014, 36(1): 121-125.







How to Cite

Li, G. (2024). Pathogenesis and Treatment Strategy of Intracranial Aneurysm. International Journal of Biology and Life Sciences, 6(2), 98-100.