Advances in Adipose-derived Mesenchymal Stem Cells for Burn Wound Healing
DOI:
https://doi.org/10.54097/r91kv866Keywords:
Adipose-derived Stem Cells, Burn Injuries, Wound Repair, Stem Cell Therapy, Regenerative MedicineAbstract
Burn injuries are under-appreciated injuries that involve tissue destruction associated with physiological and pathophysiological responses. The use of stem cell-based therapies has expanded in various diseases, particularly in burn wound repair. Adipose-derived stem cells (ADSCs) have recently been revealed as the regeneration medicine that affects ectodermal, mesodermal and endodermal tissue and organs for repairing damaged tissues. ADSCs can be easily harvested from adipose tissue and are widely used as research tools and therapeutics in preclinical and clinical wound healing trials. Based on the pathophysiology of three phases of burn injuries, we discussed various cell-based components and cytokines associated with ADSCs of three phases of burn injuries. In this review, recent research and therapeutic effects of ADSCs in burn wound are covered and stated separately in each phase. Based on the background knowledge, the differentiation potential and therapeutic applications of ADSCs is connected with these growth factors and cells. In addition, future direction and limits for ADSCs are mentioned in the final stage.
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