Synergistic antidepressant effect of Schisandra lignans and Schisandra polysaccharides

Zhengze Li

doi:10.54097/ijbls.v2i1.5160

Authors

Zhengze Li

DOI:

https://doi.org/10.54097/ijbls.v2i1.5160

Keywords:

Schisandra lignans, Schisandra polysaccharides, Synergistic antidepressant effect, Behavioral indicators

Abstract

The CUMS（Chronic unpredictable mild stress） method was used to establish a depression model，and the combination of schisandra lignans and schisandra polysaccharides was used for drug treatment, and its effect on the depressive behavior of mice was observed through behavioral indicators, and then the synergistic anti-inflammatory effects of schisandra lignans and schisandra polysaccharides were explored. The study found that the food intake of the CUMS-induced model mice decreased significantly after depression, and major symptoms such as depression, anxiety, loss of libido, and weight loss appeared. After 28 days of administration, the depression symptoms of the positive control group, Schisandra lignan group, Schisandra polysaccharide group, Schisandra lignan and polysaccharide group gradually improved, while the model group showed obvious depression. Schisandra lignans and Schisandra polysaccharides have synergistic antidepressant effects.

Downloads

Download data is not yet available.

References

Guo, W., Cao, X., Sheng, L. (2020). Expert consensus on diagnosis and treatment of depression with integrated traditional Chinese and Western medicine. Chinese Journal of Integrative Medicine, 40(02): 141-148.

J. Liu, Wei, D., Qin, X., et al. (2020).Advances in antidepressant research of combination of traditional Chinese and western medicine. Chinese Journal of Traditional Chinese Medicine, 45(16): 3776-3783.

Li, X., Gong, W., Zhou, Y., et al. (2015). Research progress on antidepressant active ingredients and their mechanism of action in Xiaoyao Powder. Chinese herbal medicine, 46(20): 3109-3116.

National Pharmacopoeia Commission. (2020). Pharmacopoeia of the People's Republic of China. China Medical Science and Technology Press, Beijing.

Hu, L., Zhang, H., Qin, L., et al. (2012). The distribution range of Schisandra chinensis in China and the impact prediction of climate change. Journal of Applied Ecology, 23(09): 2445-2450.

Xie, Q., Zhang, Q., Gu, Y., et al. (2020). Research progress on medicinal value of Schisandra chinensis. Special economic animals and plants, 23(03): 25-26.

Yu, H., Xin, L., Yang, Z., et al. (2019). Research progress on pharmacological effects of traditional Chinese medicine Schisandra chinensis. Global Chinese Medicine, 12(07): 1133-1138.

Mou, Q., He, J., Lu, Y. (2017). Application of electronic nose combined with chemometrics in the identification of Schisandra chinensis and Schisandra chinensis. Shizhen Traditional Chinese Medicine, 28(06): 1356-1359.