The Role of Genetical Factors in Bipolar Disorder and the Underlying Mechanisms

Ziyi Zhang

doi:10.54097/4mkyej59

Authors

Ziyi Zhang

DOI:

https://doi.org/10.54097/4mkyej59

Keywords:

bipolar disorder, genes, familial factor.

Abstract

Bipolar disorder (BD) is a type of mental disorder and nowadays it is more and more prevalent. It has some overlapped symptoms with some other mental disorders, including major depressive disorder (MDD) and schizophrenia (SCZ). Its familial and social factors have been largely investigated, whereas its genetic factors and relevant mechanisms still remained unclear. Several genetical loci of BD have been tested in the latest genome-wide association studies of BD. Also, familial and genetic risk factors have been found in studies of twins and families. It indicates that people who have relevant genetic variants in the family at risk may not have BD, which is astonishing. This shows the unclear relationship between the genetic and the environmental factors since the occurrence of BD is likely be a result of interactions between them. Future studies can employ longitudinal designs to explore the developmental trajectory of children with a familial risk of BD and examine the gene-environmental interactions related to BD.

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