Protective Effects of Tea Polyphenols on Alcoholic Liver-injured Mice and Alcoholic Stomach-injured Mice

Yiyang Zhou

doi:10.54097/bva8m009

Authors

Yiyang Zhou

DOI:

https://doi.org/10.54097/bva8m009

Keywords:

Tea polyphenols; Alcoholic liver injury; Gastric injury.

Abstract

The aim of this review is to investigate the protective effects of tea polyphenols on alcoholic liver injury and gastric injury and their potential mechanisms. Alcoholic liver injury and gastric injury are serious health problems caused by chronic excessive alcohol consumption, involving complex pathological mechanisms such as oxidative stress, inflammatory responses, abnormalities in immune regulation, apoptosis, disorders of lipid metabolism and fibrosis. Tea polyphenols, a class of polyphenolic compounds derived from tea, have been shown in several studies to have significant protective effects against these impairments due to their potent antioxidant and anti-inflammatory properties. This paper presents a comprehensive analysis of existing studies on tea polyphenols in the treatment of alcoholic liver injury and gastric injury, including their mechanisms of action such as antioxidant, anti-inflammatory, modulation of lipid metabolism, promotion of tissue repair, protection of the mucosal barrier, and modulation of intestinal flora. Despite the potential for clinical applications of tea polyphenols, current studies have limitations, including low bioavailability and stability issues. Future research should focus on improving the stability and bioavailability of tea polyphenols, conducting clinical studies to validate their safety and efficacy, and exploring the use of tea polyphenols in combination with other therapeutic agents. This paper provides a scientific basis for the use of tea polyphenols in the prevention and treatment of alcoholic liver injury and gastric injury and points out directions for future research.

Downloads

Download data is not yet available.

References

[1] Zhou, X., Zhao, X., Long, X., Mu, J., Pan, Y., & Qian, Y. (2019). Comparison of antioxidant effects of polyphenols from raw Puer tea in vitro and their protective effects on alcoholic gastric injury in mice. Science and Technology of Food Industry, 0(12), 300-308.

[2] Truong, V.-L., & Jeong, W.-S. (2021). Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship. International Journal of Molecular Sciences, 22(17), 9109.

[3] Wang, X. (2018). Current Status of Tea Polyphenol Research Application and Its Development Prospects. Chemical Management, 23(2), 2.

[4] Yang, X., Chen, L., Lu, H., Yang, S., & An, J. (2019). Research Progress on Extraction and Purification Methods of Tea Polyphenols and Its Functional Activities. Science and Technology of Food Industry, 40(5), 322-328, 332.

[5] Wu, Y., Li, Y., Yang, B., Yin, J., & Feng, Y. (2020). Current research on the pathogenesis of alcoholic liver disease. Journal of Clinical Hepatobiliary Diseases, 36(12), 2822-2825.

[6] Zhang, Y., Chen, S., Zhang, X., et al. (2005). Experimental study of tea polyphenols in the treatment of chronic alcoholic liver injury. Chinese Journal of Liver Diseases, 13(2), 125-127.

[7] Zhang, Y., Li, M., Hua, T., & Sun, Q. (2018). The protective effect of tea polyphenols on chronic alcoholic liver injury in rats. CJAP, 34(6), 481-484.

[8] Zhao, Q., & Zheng, L. (2016). Clinical applications of tea polyphenols in humans. Chinese Science and Technology Journal Database (Digest Edition) Medicine and Health, 9, 61-61.

[9] Zhang, S., Wang, Y., & Xu, P. (2019). Prevention of tea polyphenols on atherosclerosis and relative mechanisms. Journal of Tea Science, 39(3), 231-246.