Global Research Trends on the Effects of Cold Exposure on Fat Metabolism (1995–2025) A Bibliometric Analysis

Authors

  • Pengpeng Gou
  • Shunfang Liu
  • Sian Zhou

DOI:

https://doi.org/10.54097/c4n5yn98

Keywords:

Cold exposure, Fat metabolism, Brown adipose tissue, Thermogenesis, Energy expenditure, Obesity, Bibliometric analysis.

Abstract

This bibliometric analysis (1995–2025) highlights exponential growth and evolving trends in cold exposure research on fat metabolism. Key topics include brown adipose tissue activation, mitochondrial biogenesis, and metabolic regulation, influenced by advances in imaging technologies and translational research demands. North America and Europe lead global contributions, while collaboration across disciplines and regions remains limited. Future efforts should prioritize interdisciplinary collaboration, precision medicine approaches, and clinical translation to maximize therapeutic benefits for metabolic diseases.

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References

[1] Havel PJ. Update on Adipocyte Hormones. Diabetes. 2004 Feb 1;53(suppl_1):S143–51.

[2] Gray JI. Measurement of lipid oxidation: A review. J Am Oil Chem Soc. 1978 Jun;55(6):539–46.

[3] Dulloo AG, Seydoux J, Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiol Behav. 2004 Dec;83(4):587–602.

[4] Dulloo AG, Seydoux J, Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiol Behav. 2004 Dec;83(4):587–602.

[5] Pilz S, März W. Free fatty acids as a cardiovascular risk factor. Clin Chem Lab Med [Internet]. 2008 Jan 1 [cited 2025 Mar 3];46(4). Available from: https://www.degruyter.com/document/doi/10.1515/CCLM.2008.118/html

[6] Klingenspor M. Cold‐Induced Recruitment of Brown Adipose Tissue Thermogenesis. Exp Physiol. 2003 Jan;88(1):141–8.

[7] Chang VW, Christakis NA. Medical modelling of obesity: a transition from action to experience in a 20th century American medical textbook. Sociol Health Illn. 2002 Mar;24(2):151–77.

[8] Dombrowski SU, Knittle K, Avenell A, Araujo-Soares V, Sniehotta FF. Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials. BMJ. 2014 May 14;348(may14 6):g2646–g2646.

[9] Castellani JW, Young AJ. Human physiological responses to cold exposure: Acute responses and acclimatization to prolonged exposure. Auton Neurosci. 2016 Apr;196:63–74.

[10] Havel RJ, Goldfien A. The role of the sympathetic nervous system in the metabolism of free fatty acids. J Lipid Res. 1959 Oct;1(1):102–8.

[11] Wu G, Baumeister R, Heimbucher T. Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold. Cells. 2023 May 10;12(10):1353.

[12] White GE, Wells GD. Cold-water immersion and other forms of cryotherapy: physiological changes potentially affecting recovery from high-intensity exercise. Extreme Physiol Med. 2013 Dec;2(1):26.

[13] Peres Valgas Da Silva C, Hernández-Saavedra D, White JD, Stanford KI. Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity. Biology. 2019 Feb 12;8(1):9.

[14] Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin B, Haman F, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012 Feb 1;122(2):545–52.

[15] Dunn TL, Jones DM, Heaney JH. Cold Entropy: Assessing Individual Differences in Cognitive Adaptability during Cold Stress. Ecol Psychol. 2022 Apr 3;34(1–2):19–47.

[16] Ellegaard O, Wallin JA. The bibliometric analysis of scholarly production: How great is the impact? Scientometrics. 2015 Dec;105(3):1809–31.

[17] Cooper ID. Bibliometrics basics. J Med Libr Assoc JMLA. 2015 Oct;103(4):217–8.

[18] Kokol P, Blažun Vošner H, Završnik J. Application of bibliometrics in medicine: a historical bibliometrics analysis. Health Inf Libr J. 2021 Jun;38(2):125–38.

[19] Taşkın Z, Aydinoglu AU. Collaborative interdisciplinary astrobiology research: a bibliometric study of the NASA Astrobiology Institute. Scientometrics. 2015 Jun;103(3):1003–22.

[20] Van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010 Aug;84(2):523–38.

[21] Hassan-Montero Y, De-Moya-Anegón F, Guerrero-Bote VP. SCImago Graphica: a new tool for exploring and visually communicating data. El Prof Inf. 2022 Sep 8;e310502.

[22] Ivanova YM, Blondin DP. Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes. J Appl Physiol. 2021 May 1;130(5):1448–59.

[23] Esler M, Jennings G, Korner P, Willett I, Dudley F, Hasking G, et al. Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension. 1988 Jan;11(1):3–20.

[24] Hao Q, Yadav R, Basse AL, Petersen S, Sonne SB, Rasmussen S, et al. Transcriptome profiling of brown adipose tissue during cold exposure reveals extensive regulation of glucose metabolism. Am J Physiol-Endocrinol Metab. 2015 Mar 1;308(5):E380–92.

[25] Bargut TCL, Aguila MB, Mandarim-de CA. Brown adipose tissue: updates in cellular and molecular biology. Tissue and Cell. 2016 Oct;48(5):452–460.

[26] Chen W, Xu Z, You W, Zhou Y, Wang L, Huang Y, et al. Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy. BMC Biol. 2023 Feb 8;21(1):27.

[27] Laurberg P, Andersen S, Karmisholt J. Cold Adaptation and Thyroid Hormone Metabolism. Horm Metab Res. 2005 Sep;37(9):545–9.

[28] Barjak F, Robinson S. International collaboration, mobility and team diversity in the life sciences: impact on research performance. 2008;

[29] Ramamurthy VS. Global partnerships in scientific research and international mega-science projects. Current Science. 2011 Jun 25;100(12):1783–1785.

[30] Drury V. Gwen Sherwood PhD, RN, FAAN. J Res Nurs.

[31] Cypess AM, Williams G, Goldfine AB, Tseng YH, Kolodny GM. Identification and Importance of Brown Adipose Tissue in Adult Humans. N Engl J Med. 2009;

[32] Cypess AM, Weiner LS, Roberts-Toler C, Elía EF, Kessler SH, Kahn PA, et al. Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist. Cell Metab. 2015 Jan;21(1):33–8.

[33] Cold-Activated Brown Adipose Tissue in Healthy Men. N Engl J Med. 2009;

[34] Ouellet V, Labbé SM, Blondin DP, Phoenix S, Guérin B, Haman F, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012 Feb 1;122(2):545–52.

[35] Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, et al. Brown Adipose Tissue, Whole‐Body Energy Expenditure, and Thermogenesis in Healthy Adult Men. Obesity. 2011 Jan;19(1):13–6.

[36] Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, et al. Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest. 2013 Aug 1;123(8):3404–8.

[37] Van Der Lans AAJJ, Hoeks J, Brans B, Vijgen GHEJ, Visser MGW, Vosselman MJ, et al. Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest. 2013 Aug 1;123(8):3395–403.

[38] Van Der Lans AAJJ, Wierts R, Vosselman MJ, Schrauwen P, Brans B, Van Marken Lichtenbelt WD. Cold-activated brown adipose tissue in human adults: methodological issues. Am J Physiol-Regul Integr Comp Physiol. 2014 Jul 15;307(2):R103–13.

[39] Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, et al. Functional Brown Adipose Tissue in Healthy Adults. N Engl J Med. 2009 Apr 9;360(15):1518–25.

[40] Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, et al. High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans. Diabetes. 2009 Jul 1;58(7):1526–31.

[41] U Din M, Raiko J, Saari T, Kudomi N, Tolvanen T, Oikonen V, et al. Human brown adipose tissue [15O]O2 PET imaging in the presence and absence of cold stimulus. Eur J Nucl Med Mol Imaging. 2016 Sep;43(10):1878–86.

[42] Leitner BP, Huang S, Brychta RJ, Duckworth CJ, Baskin AS, McGehee S, et al. Mapping of human brown adipose tissue in lean and obese young men. Proc Natl Acad Sci. 2017 Aug 8;114(32):8649–54.

[43] Becher T, Palanisamy S, Kramer DJ, Eljalby M, Marx SJ, Wibmer AG, et al. Brown adipose tissue is associated with cardiometabolic health. Nat Med. 2021 Jan;27(1):58–65.

[44] Klingenspor M. Cold‐Induced Recruitment of Brown Adipose Tissue Thermogenesis. Exp Physiol. 2003 Jan;88(1):141–8.

[45] Kajimura S, Saito M. A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis. Annu Rev Physiol. 2014 Feb 10; 76(1): 225–49.

[46] Iwen KA, Backhaus J, Cassens M, Waltl M, Hedesan OC, Merkel M, et al. Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4226–34.

[47] Brito NA, Brito MN, Bartness TJ. Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation. Am J Physiol-Regul Integr Comp Physiol. 2008 May;294(5):R1445–52.

[48] Maslov LN, Vychuzhanova EA. The Role of the Sympathoadrenal System in Adaptation to Cold. Neurosci Behav Physiol. 2016 Jun;46(5):589–600.

[49] McMillan GS, Narin F, Deeds DL. An analysis of the critical role of public science in innovation: the case of biotechnology. Res Policy. 2000 Jan;29(1):1–8.

[50] Clemente-Suárez VJ, Martín-Rodríguez A, Redondo-Flórez L, López-Mora C, Yáñez-Sepúlveda R, Tornero-Aguilera JF. New Insights and Potential Therapeutic Interventions in Metabolic Diseases. Int J Mol Sci. 2023 Jun 26;24(13):10672.

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Published

26-03-2025

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How to Cite

Gou, P., Liu, S., & Zhou, S. (2025). Global Research Trends on the Effects of Cold Exposure on Fat Metabolism (1995–2025) A Bibliometric Analysis. Academic Journal of Science and Technology, 14(3), 124-135. https://doi.org/10.54097/c4n5yn98