Research progress on polyphenolic substances as α-glucosidase inhibitors

Xinze Pan

doi:10.54097/t1vf6m83

Authors

Xinze Pan

DOI:

https://doi.org/10.54097/t1vf6m83

Keywords:

Polyphenols, α-glucosidase inhibitor, Natural products, Inhibitory.

Abstract

The global prevalence of type 2 diabetes mellitus (T2DM) has surged, creating a significant health and economic burden. While synthetic α-glucosidase inhibitors (AGIs) like acarbose are used to manage postprandial hyperglycemia, their clinical application is limited by adverse gastrointestinal side effects and contraindications. This has spurred the search for safer and tolerable alternatives from natural sources. Plant-derived polyphenols are considered highly promising candidates. In recent years, there have been continuous research achievements on natural polyphenolic substances as inhibitors of α-glucosidase. This article provides a review of polyphenol substances as AGIs from the perspectives of their sources and structural characteristics, screening and extraction techniques, mechanism research, and bioavailability challenges. The purpose of this article is to provide a theoretical reference for the search for more efficient, low-cost, and environmentally friendly α-glucosidase inhibitors.

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