Center Research Situation on the Correlation Between SCFA and Ulcerative Colitis

Shangshu Li

doi:10.54097/r4g7fb76

Authors

Shangshu Li

DOI:

https://doi.org/10.54097/r4g7fb76

Keywords:

Ulcerative Colitis, SCFA, Probiotics, Dietary supplementation, Fecal microbiota transplantation.

Abstract

Ulcerative colitis (UC) is a chronic inflammatory disease of the gastrointestinal tract, characterized by mucosal damage, immune dysfunction and imbalance of the intestinal microbiota. In recent years, due to the improvement of diet and economic level, the incidence of UC has been on the rise worldwide. The human gut microbiota is a complex and dynamic microbial community that is indispensable for maintaining health and regulating the host's immune system. Among them, short-chain fatty acids refer to fatty acids with a carbon atom number less than 6, which can maintain intestinal homeostasis and exert anti-inflammatory effects. This article aims to systematically review the physiological and pathological mechanisms of SCFA in UC, as well as their application potential as therapeutic strategies. A comprehensive review is conducted on the current application status, clinical evidence and challenges of strategies such as probiotics, dietary intervention (such as high-fiber diet, Mediterranean diet) and microbiota transplantation. In order to provide theoretical basis and practical guidance for the nutrition and microecological therapy of UC.

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