Research on Applications and Optimized Design of Biosensors Based on OEGFETs

Qihang Zhao

doi:10.54097/gqv3j964

Authors

Qihang Zhao

DOI:

https://doi.org/10.54097/gqv3j964

Keywords:

OEGFET, biosensor, interface engineering, point-of-care diagnostics, flexible electronics.

Abstract

Rapid biomarker detection is essential for early disease diagnosis and point-of-care testing. Organic electrolyte-gated field-effect transistors (OEGFETs) have become attractive bioelectronic sensor platforms because they operate at low voltage, deliver high sensitivity, and can be fabricated on flexible substrates. This study systematically reviews recent technological advances to map how OEGFET-based biosensors are applied and optimized. Applications are grouped into three main areas: disease screening, health monitoring, and therapeutic evaluation. Performance is improved through interface engineering, novel materials, and refined device architectures. OEGFET biosensors reach detection limits down to 1 pM for cortisol and microRNA, and certain designs sense HIV and Parkinson’s biomarkers at femtomolar levels. Extended-gate and stretchable geometries enhance operational stability; the latest prototypes remain functional even under 100 % mechanical strain. These results highlight the potential of OEGFETs as low-cost, high-performance diagnostic tools for personalized medicine and decentralized healthcare. Coupling the sensors with wireless communication modules enables real-time physiological monitoring, bringing the technology closer to routine clinical use.

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