Application And Design Strategies of Piezoelectric Sensors for Blood Glucose Detection

Yuanhao Cheng

doi:10.54097/tzggr126

Authors

Yuanhao Cheng

DOI:

https://doi.org/10.54097/tzggr126

Keywords:

Glucose monitoring; piezoelectric biosensor; microfluidics; quality control.

Abstract

Conventional blood-based assays are accurate yet episodic and invasive, under sampling day-to-day excursions. This review examined piezoelectric (PZ) platforms for wearable, non/minimally-invasive glucose monitoring, emphasizing liquid-phase behavior and system co-design. From QCM physics, frequency shifts arise from interfacial mass and viscous-inertial loading , motivating parameter-stable readouts—phase/|Z| near (anti) resonance and ring-down time —with matched reference channels to reject bulk and thermal drift. The paper linked these choices to materials/surfaces (lead-free KNN/NKN; PVDF-based composites; Au-thiol SAMs, thin hydrogels, antifouling) and microfluidics that stabilizes the acoustic load. The paper outlined PENG-assisted architectures in which harvested motion/respiration both trickle-charge storage and act as context priors, enabling duty-cycled sensing, burst BLE/NFC, and learning-based calibration with on-device QC. Finally, the paper discussed hybridization with electrochemistry to curb false alarms under activity-dependent viscoelastic shifts, and propose reporting/validation practices (MARD, Clarke/Parkes grids, drift over wear/regeneration, controlled-sweating vs free-living robustness, and harvest-vs-consumption energy ledgers) for population-level studies across perspiration phenotypes and climates.

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