Application and Prospect of Mesenchymal Stem Cells in the Field of Skin

Muxuan Li; Yuchen Shen

doi:10.54097/1gyrb566

Authors

Muxuan Li
Yuchen Shen

DOI:

https://doi.org/10.54097/1gyrb566

Keywords:

Mesenchymal stem cells, skin regeneration, immunomodulation, wound healing, antiaging. cosmetic dermatology.

Abstract

Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent cells with fibroblast like morphology and self-renewal abilities. MSCs exhibit both immunomodulatory and paracrine signaling properties which are beneficial for the fields of skin regeneration and rejuvenation. Specifically, in the process of wound healing, MSCs inhibit excess immune activities and secrete growth factors and cytokines that aid all four stages of injury recovery. Its abundance in bone marrow, adipose tissue and umbilical cord tissue allow harmless extractions, and its immunomodulatory property also made allogeneic sources of MSCs practical in clinical settings. In skin aging, there are two main ways that the skin ages, intrinsically and extrinsically. Both routes result in an ECM that breaks down faster that it is regenerated, which induces in the formation of wrinkles, roughness, enlarged pores, and reduced elastic recoil. MSCs can be applied through the various growth factors that synthesize collagen I/III and elastin which strengthens the ECM and anti-inflammatory mediators that reduce activator proteins that breaks down ECM. The extracellular vesicles derived from MSCs further support cell regeneration. The application of MSCs in the field of skin rejuvenation holds many potentials for growth in the new future, especially in standardizing MSC products and protocols, promoting personalized MSC-based skin care, and ensuring ethical sourcing and safety assurance of MSCs.

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References

[1] Chou, Y., Alfarafisa, N. M., Ikezawa, M., et al. Progress in the Development of Stem Cell-Derived Cell-Free Therapies for Skin Aging. Clinical, cosmetic and investigational dermatology, 2023, 16, 3383 – 3406. Ankrum J A, Ong J F, Karp J M. Mesenchymal stem cells: immune evasive, not immune privileged. Nature Biotechnology, 2014, 32 (3): 252 - 260.

[2] Pittenger, M. F., Discher, D. E., Péault, B. M., et al. Mesenchymal stem cell perspective: cell biology to clinical progress. Npj Regenerative Medicine, 2019, 4 (1).

[3] Viswanathan, S., Shi, Y., Galipeau, J., Krampera, M., Leblanc, K., Martin, I., Nolta, J., Phinney, D., & Sensebe, L. Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT®) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy, 21 (10), 1019 – 1024. 2019.

[4] Wu, Y., Fu, J., Huang, Y., et al. Biology and function of pericytes in the vascular microcirculation. Animal Models and Experimental Medicine, 2023, 6 (4), 337 – 345.

[5] Caplan, A. I., & Correa, D. The MSC: an injury drugstore. Cell Stem Cell, 2011, 9 (1), 11 – 15.

[6] Ankrum J A, Ong J F, Karp J M. Mesenchymal stem cells: immune evasive, not immune privileged. Nature Biotechnology, 2014, 32 (3): 252 - 260.

[7] Jo, H., Brito, S., Kwak, B. et al. Applications of mesenchymal stem cells in skin regeneration and rejuvenation. International Journal of Molecular Sciences, 2021, 22 (5), 2410.

[8] De Vasconcellos Machado, C., Da Silva Telles, P. D., & Nascimento, I. L. O. Immunological characteristics of mesenchymal stem cells. Revista Brasileira De Hematologia E Hemoterapia, 2013, 35 (1), 62 – 67.

[9] Jeschke, M. G., Rehou, S., McCann, M. R., et al. Allogeneic mesenchymal stem cells for treatment of severe burn injury. Stem Cell Research & Therapy, 10 (1). 2019.

[10] He, X., Dong, Z., Cao, Y., et al. MSC-Derived exosome promotes M2 polarization and enhances cutaneous wound healing. Stem Cells International, 2019, 1 – 16.

[11] Ellis, S., Lin, E. J., & Tartar, D. Immunology of Wound Healing. Current dermatology reports, 7 (4), 350 – 358. 2018.

[12] El-Sayed, M. E., Atwa, A., Sofy, A. R., et al. Mesenchymal stem cell transplantation in burn wound healing: uncovering the mechanisms of local regeneration and tissue repair. Histochemistry and Cell Biology, 161 (2), 165 – 181. 2023.

[13] Schulman, C. I., Namias, N., Pizano, L., et al. The effect of mesenchymal stem cells improves the healing of burn wounds: a phase 1 dose-escalation clinical trial. Scars Burns & Healing, 2022, 8.

[14] Dung TN, Han VD, Tien GN, et al. Autologous Adipose-Derived Stem Cell (Adsc) Transplantation in the Management of Chronic Wounds. Ann Burns Fire Disasters. 34 (4): 343 - 350. PMID: 35035328; PMCID: PMC8717910. Dec 2021.

[15] Zhang, S., & Duan, E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell transplantation, 2018, 27 (5), 729 – 738.

[16] Zare, S., Jafarzadeh, A., Zare, S., & Shamloo, A. Exploring the dermatological applications of human mesenchymal stem cell secretome: a comprehensive review. Stem cell research & therapy, 2025, 16 (1), 177.

[17] Varani, J., Dame, M. K., Rittie, L., et al. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. The American journal of pathology, 168 (6), 1861 – 1868. 2006.

[18] Nan, L., Guo, P., Hui, W., et al Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies. Frontiers in pharmacology, 16, 1592596. 2025.

[19] Shao, Y., Qin, Z., Alexander Wilks, J., et al. Physical properties of the photodamaged human skin dermis: Rougher collagen surface and stiffer/harder mechanical properties. Experimental dermatology, 28 (8), 914 – 921. 2019.

[20] Wong, RY., Ng, NS., Brianna, B. et al. Role of Mesenchymal Stem Cells in Skin Aging and Damage: Insights from Recent Preclinical and Clinical Studies. Curr Stem Cell Rep, 2025, 11, 4. Chouaib, B., Haack-Sørensen, M., Chaubron, F. et al. Towards the Standardization of Mesenchymal Stem Cell Secretome-Derived Product Manufacturing for Tissue Regeneration. International Journal of Molecular Sciences, 2023, 24 (16), 12594.

[21] Chouaib, B., Haack-Sørensen, M., Chaubron, F. et al. Towards the Standardization of Mesenchymal Stem Cell Secretome-Derived Product Manufacturing for Tissue Regeneration. International Journal of Molecular Sciences, 2023, 24 (16), 12594.

[22] Liang, X., Li, J., Yan, Y., et al. Efficacy of Microneedling Combined with Local Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells Conditioned Media in Skin Brightness and Rejuvenation: A Randomized Controlled Split-Face Study. Frontiers in medicine, 2022, 9, 837332.

[23] Czajkowska, J., Juszczyk, J., Bugdol, M. N., et al. High-frequency ultrasound in anti-aging skin therapy monitoring. Scientific reports, 13 (1), 17799. 2023.

[24] Mariane Massufero Vergilio, Samara Flamini Kiihl, João Batista Florindo, et al. Enhancing skin aging parameter assessment in clinical trials: AI-Driven analysis of ultrasound images, Biomedical Signal Processing and Control, 2025, Volume 100, Part C, 106962, ISSN 1746 - 8094.

[25] Noor Azlan, N. A. B., Vitus, V., Nor Rashid, N. et al. Human mesenchymal stem cell secretomes: Factors affecting profiling and challenges in clinical application. Cell Tissue Res, 2024, 395, 227 – 250.