Can The Ketogenic Diet Improve Autism Spectrum Disorder? From Perspectives on Diversity Interventions and Treatment
DOI:
https://doi.org/10.54097/ehss.v22i.12413Keywords:
Autism Spectrum Disorder; Ketogenic Diet; Behavioral therapies; Depression; Gastrointestinal Issues.Abstract
Autism spectrum disorder (ASD) is an extensive spectrum of abnormalities, inclusive of metabolic, mitochondrial, immune, inflammatory, and behavioral dysfunction in multiple parts of the body, resulting in multiple symptoms and disrupting an individual’s ability to communicate, form relationships, develop life skills, explore, play, and learn. In recent years, the low-carbohydrate, high-fat ketogenic diet (KD) has gained popularity and been viewed as a promising non-pharmacological treatment for patients with ASD. Not only has this dietary regimen been successfully used in treating pediatric epilepsy, one of common co-occurring ASD symptoms, for over a century, but some studies have also been shown beneficial effects in lessening various other comorbid disorders (e.g., seizures and mood disorders) and behavioral deficits. This article's major objective is to briefly retrospected the literature pertaining to the feasibility and the efficacy of dietary/nutritional interventions in treating ASD-related conditions, including KD and probiotics intakes, along with behavioral therapies, consisting of applied behavior analysis (ABA) and cognitive-behavioral therapy (CBT).
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Schreibman, L., Dawson, G., Stahmer, A. C., Landa, R., Rogers, S. J., McGee, G. G., ... & Halladay, A. Naturalistic developmental behavioral interventions: Empirically validated treatments for autism spectrum disorder. Journal of autism and developmental disorders, 2015, 45, 2411-2428.
American Psychiatric A. Diagnostic and statistical manual of mental disorders: DSM-5. Arlington, VA: American Psychiatric Association; (2013).
Maenner, M. J., Warren, Z., Williams, A. R., Amoakohene, E., Bakian, A. V., Bilder, D. A., ... & Shaw, K. A. Prevalence and characteristics of autism spectrum disorder among children aged 8 years—Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2020. MMWR Surveillance Summaries, 2023, 72(2), 1.
Cheroni, C., Caporale, N., & Testa, G. Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology. Molecular autism, 2020, 11(1), 69.
Gjevik, E., Eldevik, S., Fjæran-Granum, T., & Sponheim, E. Kiddie-SADS reveals high rates of DSM-IV disorders in children and adolescents with autism spectrum disorders. Journal of autism and developmental disorders, 2011, 41, 761-769.
Restrepo, B., Angkustsiri, K., Taylor, S. L., Rogers, S. J., Cabral, J., Heath, B., ... & Nordahl, C. W. Developmental–behavioral profiles in children with autism spectrum disorder and co‐occurring gastrointestinal symptoms. Autism Research, 2020, 13(10), 1778-1789.
Karhu, E., Zukerman, R., Eshraghi, R. S., Mittal, J., Deth, R. C., Castejon, A. M., ... & Eshraghi, A. A. Nutritional interventions for autism spectrum disorder. Nutrition reviews, 2020, 78(7), 515-531.
Politte, L.C., Howe, Y., Nowinski, L. et al. Evidence-Based Treatments for Autism Spectrum Disorder. Curr Treat Options Psych2, 2015, 38–56.
Dyńka, D., Kowalcze, K., & Paziewska, A. The Role of Ketogenic Diet in the Treatment of Neurological Diseases. Nutrients, 2022, 14(23), 5003.
Dowis, K., & Banga, S. The Potential Health Benefits of the Ketogenic Diet: A Narrative Review. Nutrients, 2021, 13(5), 1654.
Jensen, N. J., Wodschow, H. Z., Nilsson, M., & Rungby, J. Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases. International journal of molecular sciences, 2020, 21(22), 8767.
Danan, A., Westman, E. C., Saslow, L. R., & Ede, G. The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients. Frontiers in psychiatry, 2022, 13, 951376.
BACB (2014). Applied Behaviour Analysis Treatment of Autism Spectrum Disorder: Practice Guidelines for Healthcare Funders and Managers (2nd ed.). Behaviour Analyst Certification Board.
Yu, Y., Huang, J., Chen, X., Fu, J., Wang, X., Pu, L., Gu, C., & Cai, C. Efficacy and Safety of Diet Therapies in Children With Autism Spectrum Disorder: A Systematic Literature Review and Meta-Analysis. Frontiers in neurology, 2022, 13, 844117.
Rao, T. S., Asha, M. R., Ramesh, B. N., & Rao, K. J. Understanding nutrition, depression and mental illnesses. Indian journal of psychiatry, 2008, 50(2), 77.-depression+nutrition interventions/B12/Calsium
Aucoin, M., LaChance, L., Naidoo, U., Remy, D., Shekdar, T., Sayar, N., Cardozo, V., Rawana, T., Chan, I., & Cooley, K. Diet and Anxiety: A Scoping. Nutrients, 2021, 13(12), 4418.
Ricci, A., Idzikowski, M. A., Soares, C. N., & Brietzke, E. Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet. Reviews in the neurosciences, 2020, 31(6), 637–648.
Margolis, K. G., Cryan, J. F., & Mayer, E. A. The Microbiota-Gut-Brain Axis: From Motility to Mood. Gastroenterology, 2021, 160(5), 1486–1501.
Aucoin, M., LaChance, L., Naidoo, U., Remy, D., Shekdar, T., Sayar, N., Cardozo, V., Rawana, T., Chan, I., & Cooley, K. Diet and Anxiety: A Scoping Review. Nutrients, 2021, 13(12), 4418.
Ekinci, G. N., & Sanlier, N. The relationship between nutrition and depression in the life process: A mini-review. Experimental gerontology, 2023, 172, 112072.
Williams, B. L., Hornig, M., Buie, T., Bauman, M. L., Cho Paik, M., Wick, I., Bennett, A., Jabado, O., Hirschberg, D. L., & Lipkin, W. I. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PloS one, 2011, 6(9), e24585.
Krajmalnik-Brown, R., Lozupone, C., Kang, D. W., & Adams, J. B. Gut bacteria in children with autism spectrum disorders: challenges and promise of studying how a complex community influences a complex disease. Microbial Ecology in Health and Disease, 2015, 26(1), 26914.
Gorrindo, P., Williams, K. C., Lee, E. B., Walker, L. S., McGrew, S. G., & Levitt, P. Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism research, 2012, 5(2), 101-108.
Youngson, N. A., Morris, M. J., & Ballard, J. W. O. The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs. Seizure, 2017, 52, 15–19.
Li, Q., Liang, J., Fu, N., Han, Y., & Qin, J. A Ketogenic Diet and the Treatment of Autism Spectrum Disorder. Frontiers in pediatrics, 2021, 9, 650624.
Wood, J. J., Kendall, P. C., Wood, K. S., Kerns, C. M., Seltzer, M., Small, B. J., ... & Storch, E. A. Cognitive behavioral treatments for anxiety in children with autism spectrum disorder: a randomized clinical trial. JAMA psychiatry, 2020, 77(5), 474-483.
Ekman, E., & Hiltunen, A. J. Modified CBT using visualization for Autism Spectrum Disorder (ASD), anxiety and avoidance behavior--a quasi-experimental open pilot study. Scandinavian journal of psychology, 2015, 56(6), 641–648.
Mayes, S. D., & Zickgraf, H. Atypical eating behaviors in children and adolescents with autism, ADHD, other disorders, and typical development. Research in Autism Spectrum Disorders, 2019, 64, 76-83.
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