Analysis of the Relationship Between IL-10 Gene Polymorphism and Hypertension Susceptibility in Han Nationality in Jianghan Plain


  • Feng Cao
  • Yinchun Yang
  • Wenli Xu
  • Siqi Liu
  • Xu Wu
  • Xianglin Cheng



Iinterleukin-10, Hypertension, Gene polymorphism, Han nationality, Chinese.


Objective: To analyze the association between interleukin-10 (IL-10) promoter-1082 and -819 polymorphisms and hypertension in Han nationality in Jianghan Plain. Methods: A total of 50 Han patients with hypertension in Jianghan Plain, who were hospitalized in our hospital from March 2018 to April 2018, were selected as the experimental group. 50 healthy Han Chinese people in Jianghan Plain were selected as the control group. After a series of reactions such as genomic DNA extraction and PCR amplification, polymorphisms of IL-10-819 and -1082 were performed using ABI's BAT3.1 sequencing kit. Analysis and analysis of the risk of developing hypertension at each point. Results: There were three genotypes of C/C, C/T and T/T in the IL-10-819 locus. There was no significant difference between the two groups (P>0.05). There were G/G, G/A and A/A genotypes in IL-10-1082 loci in both groups. There was no significant difference between the two groups (P>0.05). Logistic regression analysis showed that compared with IL-10-819C/C genotype, the risk of hypertension in the population carrying IL-10-819C/T and T/T genotypes was OR=1.19 (95%CI=0.71~1.05), χ=0.73, P>0.05, OR=1.05 (95%CI=1.01~1.10), χ=0.96,P>0.05, the difference was not statistically significant (P>0.05). Compared with IL-10-1082A/A, the risk of developing hypertension in the population expressing IL-10-1082G/A and G/G genotypes was OR=1.2 (95%CI=0.76~1.12), χ=0.704, P>0.05, OR=1.33 (95% CI=0.77~1.33), χ=0.97, P>0.05, the difference was not statistically significant (P>0.05). Conclusion: The distribution of genotypes and alleles of IL-10-819 and -1082 loci in Han patients with hypertension and healthy people in Jianghan Plain is similar, and the genotype mutations of IL-10-819 and -1082 are irrelevant with hypertension.


Yufen Gao,Jingkai Chan and Gangjun Chung.Changes of microalbuminuria and inflammatory factors in prehypertensive population[J].Chongqing Medical Journal,2014,43(21):2788-2791.

Anand R,Nair, Philip J.Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells[J].Experimental Cell Research,2015,335(2): 238-247.

Zhaopeng Chou,Zujian Hui and Xiaohua Day.Relationship between essential hypertension and inflammatory factors and intervention of traditional Chinese medicine[J].Journal of Traditional Chinese Medicine and Clinical Medicine, 2015, 27(3): 307-310.

Hua Chang, Lixiang Liu and Zhi Liu. Changes and significance of serum IL-6, IL-10 and TNF-α levels in patients with diabetes mellitus complicated with hypertension[J].Shandong Medical Journal ,2015,55(19):79-80.

China Hypertension Prevention and Treatment Guidelines Revision Committee. China Guidelines for Prevention and Treatment of Hypertension 2010[J].Chinese Journal of Hypertension, 2011; 19(8): 701-743.

Ruicheng Hu,Yongjian Xu ,Zhenxiang Chang and et. Relationship between interleukin-10 gene promoter polymorphism and susceptibility to chronic obstructive pulmonary disease [J]. Chinese Journal of Medical Genetics, 2003; 20:503-507.

Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease [J]. Nature Medicine, 2012, 18(3): 363–374.

Zhaohui Chiang,Jianjun Wong and Wenmin Chan. Determination and significance of TNF-α and NF-κB in serum of patients with essential hypertension[J].Medical Clinical Research, 2014,31(3):527-530.



5 September 2022

How to Cite

Cao, F., Yang, Y., Xu, W., Liu, S., Wu, X., & Cheng, X. (2022). Analysis of the Relationship Between IL-10 Gene Polymorphism and Hypertension Susceptibility in Han Nationality in Jianghan Plain. Academic Journal of Science and Technology, 2(3), 84–87.