Preparation and Performance of Acrylate Hydrogel Nanocomposite Adjuvant
DOI:
https://doi.org/10.54097/05ww4771Keywords:
Hydrogel, Nanocomposite Adjuvant, Agonist, PhagocytosisAbstract
In order to meet the urgent need of developing novel vaccine adjuvants with rapid development in the field of biomedicine, a novel acrylate hydrogel nanocomposite adjuvant with biological safety and cell targeting was prepared by compounding polyacrylate nanoemulsion, which can form antigen reservoir, with TLR3 agonist Poly I:C. The microscopic morphology of the composite adjuvant was observed, and its particle size, zeta potential, and rheological properties were characterized and analyzed. The composite adjuvant exhibited a particle size of less than 50 nm and a cell viability of 75.59% at Poly I:C concentration of 10 μg/mL, showing good biocompatibility. Furthermore, the composite adjuvant showed significant cell targeting and enhanced antigen phagocytosis capabilities. This study provides a new approach for developing composite adjuvant systems with synergistic immune-enhancing functions, demonstrating promising application potential.
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