Synthesis of the Amino Acid-based Polyesteramide for Hydrophilic Modification of Polycaprolactone

Xiaoqi Chen; Lu Bai; Mingguang Hu; Haijun Zhou; Fen Zhang; Yantao Li

doi:10.54097/bjdaat18

Authors

Xiaoqi Chen
Lu Bai
Mingguang Hu
Haijun Zhou
Fen Zhang
Yantao Li

DOI:

https://doi.org/10.54097/bjdaat18

Keywords:

Polycaprolactone (PCL), Amino Acid-based Polyesteramides (AA-PEAs), Hydrophilic Modification, Water Contact Angle

Abstract

To solve the problem that the strong hydrophobicity of Polycaprolactone (PCL) was not conducive to cell adhesion and spreading in artificial blood vessels, the amino acid-based polyesteramides (AA-PEAs) material was synthesized using L-phenylalanine, 1,3-propylene glycol and sebacyl chloride for hydrophilic modification of PCL. The chemical structure, water contact angles, and thermal performance, were characterized by ¹H NMR, Water contact Angle tester, Thermogravimetric Analyzer, and Differential Scanning Calorimeter. The hydrophilicity of PCL fiber membranes was significantly improved by adding the AA-PEAs. The glass transition temperature (T_g) of the PCL fiber membrane was 34.1℃, which was lower than the human body temperature with the 30% content of AA-PEAs. The melting temperature (T_m) was 55.0℃, which was higher than the human body temperature. It is conducive to maintaining good flexibility under the impact and pressure of blood flow in the body.

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References

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