Elucidating the Bioactive Compounds and Integrative Strategies of Qibai Powder for Multi-Target Intervention in Melasma

Chenxi Liu; Weiying Liang; Xiaoshu Li; Yingni  Wu; Yuanqi Cai; Yao Zhang

doi:10.54097/0xr7es65

Authors

Chenxi Liu
Weiying Liang
Xiaoshu Li
Yingni Wu
Yuanqi Cai
Yao Zhang

DOI:

https://doi.org/10.54097/0xr7es65

Keywords:

Qibai Powder, Melasma, Network Pharmacology, Signaling Pathways, Multi-Target Regulation

Abstract

Objective:To investigate the active components and mechanisms of action of Qibai Powder in treating melasma. Methods: Screening of drug active components was conducted using the TCMSP and HERB databases, combined with the GeneCards database to obtain disease targets. An intersection of targets was used to construct a protein-protein interaction (PPI) network diagram, followed by Gene Ontology (GO) functional enrichment and KEGG pathway enrichment analysis. Molecular docking between core components and key targets was performed using AutoDock vina software. Results: Twenty-five active components were identified, acting on 290 disease targets. Pathway enrichment analysis indicated Qibai Powder primarily mediates cancer pathways, lipid metabolism, and therosclerosis by regulating targets such as TP53 and ESR1. Molecular docking revealed high affinity between key targets and core components. Conclusion: Qibai Powder exerts therapeutic effects on melasma through multi-component, multi-target, and multi-pathway mechanisms; however, specific action mechanisms require further validation.

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References

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