Clinical Significance of Serum Creatinine, Urea Nitrogen and Uric Acid Levels in Patients with Chronic Renal Failure

Abstract

Chronic renal failure (CRF) is a clinical syndrome characterized by chronic progressive renal parenchymal damage caused by various reasons, resulting in obvious atrophy of the kidney and inability to maintain basic functions. Metabolite retention, imbalance of water, electrolyte and acid-base balance, and systemic involvement of various systems are the main manifestations in clinic. Due to its complicated metabolic disorder, once it develops to the stage of renal failure or even the end stage of uremia, it is often more difficult to treat other renal diseases. Therefore, early detection, early diagnosis and early treatment of chronic renal failure are of great significance to improve the therapeutic effect of patients. In this project, 150 subjects were divided into chronic renal failure group (75 cases) and healthy group (75 cases). By analyzing the data of renal function indexes (blood creatinine, urea nitrogen, uric acid) of patients with chronic renal failure and healthy control group, the clinical significance of blood creatinine, urea nitrogen and uric acid level detection for chronic renal failure was discussed, and the importance of blood creatinine, urea nitrogen and uric acid monitoring for chronic renal failure was explained, providing scientific basis for timely prevention or delay of chronic renal failure. Biochemical tests were carried out on 150 serum samples from the combined healthy group of chronic renal failure. the values of uric acid, urea nitrogen and serum creatinine detected by the two groups were counted and treated with statistical methods. the results showed that the values of urea nitrogen, uric acid and serum creatinine in the chronic renal failure group were significantly higher than those in the healthy group, and the same indexes in the two groups were compared, P<0.05. statistics showed that the difference of the same data between the two groups was significant. Serum uric acid, urea nitrogen and creatinine are easy to detect and the test results are relatively accurate. The results can be used for auxiliary diagnosis of patients with chronic renal failure and have clinical significance for diagnosis of patients with chronic renal failure.