Research Progress of M22 Intense Pulsed Light in the Field of Ophthalmology

Lijun Yang; Baohua Wu; Yuerong Kong; Jieqiong Liu; Yan Sun; Rui Ding

doi:10.54097/2264gh06

Authors

Lijun Yang
Baohua Wu
Yuerong Kong
Jieqiong Liu
Yan Sun
Rui Ding

DOI:

https://doi.org/10.54097/2264gh06

Keywords:

M22 Intense Pulsed Light, Ophthalmic Diseases, Periorbital Skin Treatment, Research Progress

Abstract

This study reviews the application of M22 Intense Pulsed Light (IPL) technology in the field of ophthalmology. It elaborates on the evolutionary history and theoretical basis of this technology, and conducts an in-depth analysis of its latest research progress in the treatment of ophthalmic diseases (such as dry eye disease and retinal vascular diseases) as well as periorbital skin disorders. Meanwhile, this paper also evaluates the safety of this therapeutic method and its potential adverse reactions. Looking ahead, through continuous technological improvement, expansion of therapeutic indications and exploration of combined treatment regimens, M22 IPL technology is expected to significantly promote the advancement of ophthalmic medicine and provide innovative perspectives and methods for the treatment strategies of ophthalmic diseases.

Downloads

Download data is not yet available.

References

[1] Liu Yongsheng, Xiao Rong, Modern Laser Cosmetology, Beijing: People's Medical Publishing House, 2019.

[2] Dan, Luo, Yan, et al. Impact of intense pulse light irradiation on BALB/c mouse skin—in vivo study on collagens, matrix metalloproteinases and vascular endothelial growth factor[J]. Lasers in Medical Science, 2009.DOI: 10.1007/s10103-007-0529-8.

[3] Wang Degui, Lin Dusheng, Du Guangjin, et al. The efficacy of M2 optimized pulsed light in treating dry eye caused by meibomian gland dysfunction [J]. Journal of Ophthalmology, 2017, 32(4): 223-228.

[4] Wu Yuping, Cen Zhimin, Liu Shui. The influence of M22 optimized intense pulsed light therapy on the tear meniscus height of patients with dry eye caused by meibomian gland dysfunction [J]. Medical Equipment, 2022, 35(9): 94-96.

[5] Gontijo LC, Morte ISB, Cardoso Neto J. Pulsed light therapy for the treatment of dry eyes: retrospective analysis of a series of cases. Rev. bras.oftalmol.2025;84:e0013.

[6] Whang WJ,Yun JM,Koh K.Intense pulsed-light treatment improves objective optical quality in patients with meibomian gland dysfunction[J].BMC Ophthalmology, 2023, 23.DOI:10. 1186/ s12886-023-02939-9.

[7] Kudrna JJ,Nguyen C, Vora GK.Intense Pulse Light Therapy for Meibomian Gland Dysfunction[J].Current Ophthalmology Reports,2022,10(4):138-152.DOI:10.1007/s40135-022-00297-1.

[8] Toyos R. Intense,Pulsed Light for Dry Eye Syndrome The light acts as a warm compress that liquifies the meibomian gland's secretions and ultimately unplugs them[J].Cataract & Refractive Surgery Today,2009.

[9] Toyos R, Toyos M, Willcox J,et al.Evaluation of the Safety and Efficacy of Intense Pulsed Light Treatment with Meibomian Gland Expression of the Upper Eyelids for Dry Eye Disease.[J].Photobiomodulation, photomedicine, and laser surgery, 2019, 37(9):527-531.DOI:10.1089/photob.2018.4599.

[10] Zhang X Z , Song N , Gong L .Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis[J].Current Eye Research, 2018, 44(3).DOI:10.1080/02713683.2018.1536217.

[11] Li H , Huang L , Fang X ,et al.The photothermal effect of intense pulsed light and LipiFlow in eyelid related ocular surface diseases: Meibomian gland dysfunction, Demodex and blepharitis[J].Heliyon, 2024, 10(13).DOI:10. 1016/j. heliyon. 2024. e33852.

[12] Chen Jingling, Zeng Chalian. Effects of Optimized Intense Pulsed Light Therapy on Meibomian Gland Function and Corneal Epithelial Healing in Patients with Blepharitis-Associated Dry Eye [J]. Chinese Journal of Biomedical Engineering (English Edition), 2024, 33(4): 143-149.

[13] Shergill M, Khaslavsky S , Avraham K M I .A Review of Intense Pulsed Light in the Treatment of Ocular Rosacea[J]. Journal of cutaneous medicine and surgery, 2024, 28(4):370-374. DOI:10.1177/12034754241254051.

[14] Sella R. Intense Pulsed Light Therapy with Optimal Pulse Technology as an Adjunct Therapy for Moderate to Severe Blepharitis-Associated Keratoconjunctivitis[J].Journal of Ophthalmology, 2019, 2019:1-10.DOI:10.1155/2019/3143469.

[15] Martínez-Hergueta, María C,Alió del Barrio, Jorge L, Canto-Cerdan M ,et al.Efficacy and safety of intense pulsed light direct eyelid application[J].Scientific Reports, 2022, 12(1). DOI: 10.1038/s41598-022-17986-3.

[16] Lee,WW,Murdock,et al.Ocular damage secondary to intense pulse light therapy to the face.[J].Ophthalmic Plastic & Reconstructive Surgery, 2011.DOI:10. 1097/IOP. 0b013e31 820c6e23.

[17] Shami M E, Maroun A , Hoyek S ,et al.Optimized combined low level light therapy and intense pulsed light therapy for the treatment of dry eye syndrome caused by Meibomian glands dysfunction.[J].Journal francais d'ophtalmologie, 2022.DOI: 10. 1016/ j.jfo.2022.03.015.

[18] Martinez-De-La-Casa J M , Oribio-Quinto C , Milans-Del-Bosch A ,et al.Intense pulsed light-based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops[J].Eye and vision (London, England), 2022, 9(1):12.DOI:10.1186/s40662-022-00284-4.