Analysis of Survival Rate and Influencing Factors in Surgical Treatment of Primary Hepatocellular Carcinoma

Abstract

Objective: To study the survival rate of patients with primary hepatocellular carcinoma (HCC) undergoing clinical surgical treatment and various influencing factors, with the aim of further improving the survival rate of primary HCC patients. Methods: Sixty patients with primary hepatocellular carcinoma who underwent liver cancer resection surgery between January 2020 and December 2022 in our hospital were selected. A retrospective analysis was conducted on the patients' clinical characteristics (family medical history, alpha-fetoprotein levels, degree of liver cirrhosis, vascular invasion), treatment methods (surgical techniques, adjunctive therapies), and prognosis. The survival rate of patients and the influencing factors on the postoperative survival rate were analyzed. Results: There was a statistically significant difference in the five-year survival rate comparisons between different liver cirrhosis statuses, tumor sizes, preoperative alpha-fetoprotein levels, vascular invasion statuses, adjunctive treatment methods, and family medical histories (P < 0.05). Comparisons between different genders, ages, tumor locations, tumor pathological types, hepatitis B surface antigens, Child-Pugh classifications of liver function, tumor numbers, and methods of liver cancer resection showed no statistically significant differences (P > 0.05). Liver cirrhosis, tumor size ≥ 5cm, preoperative alpha-fetoprotein level > 400ng/ml, change in alpha-fetoprotein levels pre-and post-surgery, vascular invasion, adjunctive treatment methods, and PLC family medical history are independent factors influencing the survival rate of surgical treatment in primary HCC patients. Conclusion: There are several factors affecting the postoperative survival rate of primary HCC patients. Clinicians need to take a comprehensive approach. For high-risk patients, regular follow-ups are necessary, coupled with early diagnosis and treatment, to improve the prognosis. This approach is worth promoting.