Recent Advances in Photodynamic Therapy in the Treatment of Dental Diseases

Authors

  • Xuan Liu
  • Xiaolin Zhao
  • Rui Han
  • Chang Liu
  • Jianqi Gu
  • Wenhui Wu

DOI:

https://doi.org/10.54097/2xds4124

Keywords:

Photodynamic Therapy, Caries, Periodontal Disease, Endodontics, Oral Squamous Cell Carcinoma

Abstract

Photodynamic Therapy (PDT) is a new technology that utilizes the photodynamic effect for disease diagnosis and treatment. Its action is based on the photodynamic effect. It is a kind of photosensitization reaction accompanied by biological effects with the participation of oxygen molecules. The process is that specific wavelength laser irradiation causes the photosensitizer absorbed by the tissue to be excited, and the photosensitizer in the excited state passes the energy to the surrounding oxygen, generating highly reactive singlet oxygen, which undergoes oxidative reaction with neighboring biological macromolecules to produce cytotoxicity, which leads to cellular damage and even death. Current research shows that photodynamic therapy shows great advantages in the treatment of caries, periodontal disease and oral squamous carcinoma. This paper mainly provides a further overview of the current status of research at home and abroad on the application of photodynamic therapy in the treatment of dental diseases in recent years.

Downloads

Download data is not yet available.

References

Siddiqui A Z, Vellappally S, Fouad H, et al. Bactericidal and clinical efficacy of photochemotherapy in acute necrotizing ulcerative gingivitis.[J/OL]. Photodiagnosis and photodynamic therapy, 2020, 29: 101668.

Pourhajibagher M, Bahrami R, Bahador A. Application of photosensitive dental materials as a novel antimicrobial option in dentistry: A literature review.[J/OL]. Journal of dental sciences, 2024, 19(2): 762-772.

Vieira L D S, Mandetta A R H, Bortoletto C C, et al. A minimal interventive protocol using antimicrobial photodynamic therapy on teeth with molar incisor hypomineralization: A case report.[J/OL]. Journal of biophotonics, 2024, 17(3): e202300414.

Almohareb T, Al Ahdal K, Maawadh A M, et al. Bleached enamel reversal using grape seed extract, green tea, curcumin-activated photodynamic therapy, and Er: YAG on microleakage and bond integrity of composite material bonded to the enamel surface.[J/OL]. Photodiagnosis and photodynamic therapy, 2024, 45: 103943.

Liu W, Sun Y, Zhou B, et al. Near-infrared light triggered upconversion nanocomposites with multifunction of enhanced antimicrobial photodynamic therapy and gas therapy for inflammation regulation.[J/OL]. Journal of colloid and interface science, 2024, 663: 834-846.

Liu H, Chen Y, Mo L, et al. “Afterglow” Photodynamic Therapy Based on Carbon Dots Embedded Silica Nanoparticles for Nondestructive Teeth Whitening.[J/OL]. ACS nano, 2023, 17(21): 21195-21205.

Kattan H F. The efficacy of antimicrobial photodynamic therapy in the disinfection of coronal and radicular dentine of primary teeth: A systematic review and meta-analysis.[J/OL]. Photodiagnosis and photodynamic therapy, 2023, 44: 103697.

De Araújo L P, Marchesin A R, Carpena L P, et al. Outcome of curcumin-based photodynamic therapy in endodontic microsurgery: A case report.[J/OL]. Photodiagnosis and photodynamic therapy, 2024, 45: 103994.

Yang G, Chen W. In vitro effects of Er: YAG laser-activated photodynamic therapy on Enterococcus faecalis in root canal treatment.[J/OL]. Photodiagnosis and photodynamic therapy, 2024, 45: 103992.

Pourhajibagher M, Ghafari H A, Bahrami R, et al. Photoinactivation of Enterococcus faecalis Biofilm: In Vitro Antimicrobial Effect of Photoexcited Rutin-Gallium(III) Complex via Visible Blue Light.[J/OL]. Journal of endodontics, 2024.

Zafari J, Karkehabadi H, Jamali S, et al. Evaluation of cytotoxicity impacts of combined methylene blue-mediated photodynamic therapy and intracanal antibiotic medicaments on dental stem cells.[J/OL]. Photodiagnosis and photodynamic therapy, 2024, 45: 103955.

Sharifzadeh S S, Gerami Amin M, Moezzi Ghadim N, et al. Comparative Analysis of Photosensitizer Penetration Depth in Root Canal Debridement for Endodontic Disinfection.[J/OL]. Iranian endodontic journal, 2024, 19(1): 35-38.

Mehrotra R, Gupta S, Siddiqui Z R, et al. Clinical efficacy of ozonated water and photodynamic therapy in non-surgical management of chronic periodontitis: A clinico- microbial study.[J/OL]. Photodiagnosis and photodynamic therapy, 2023, 44: 103749.

Sun X L, Dai A N, Xu S Y, et al. [Healing effect of photodynamic therapy on extraction sockets of periodontally compromised teeth: a randomized, controlled, superiority clinical trial].[J/OL]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2024, 59(4): 326-335.

Nie M, Zhang P, Pathak J L, et al. Photodynamic therapy in periodontitis: A narrative review.[J/OL]. Photodermatology, photoimmunology & photomedicine, 2024, 40(1): e12946.

Shahmoradi M, Narimani T, Najafi F, et al. Antimicrobial photodynamic therapy with dendrosomal curcumin and blue laser against Porphyromonas gingivalis.[J/OL]. Photodiagnosis and photodynamic therapy, 2023, 44: 103825.

Hayashi J I, Ono K, Iwamura Y, et al. Suppression of subgingival bacteria by antimicrobial photodynamic therapy using transgingival irradiation: A randomized clinical trial.[J/OL]. Journal of periodontology, 2023.

Ou J, Gao Y, Li H, et al. Application of 5-aminolevulinic acid-mediated Waterlase-assisted photodynamic therapy in the treatment of oral leukoplakia.[J/OL]. Scientific reports, 2022, 12(1): 9391.

Xing R, Liu Y, Zou Q, et al. Self-assembled injectable biomolecular hydrogels towards phototherapy.[J/OL]. Nanoscale, 2019, 11(46): 22182-22195.

Lin L, Song C, Wei Z, et al. Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia.[J/OL]. Journal of nanobiotechnology, 2022, 20(1): 106.

Xu Y, Yang L, Wang C, et al. Ferroptosis boosted oral cancer photodynamic therapy by carrier-free Sorafenib-Ce6 self-assembly nanoparticles.[J/OL]. Journal of controlled release : official journal of the Controlled Release Society, 2024, 366: 798-811.

Shu Z, Li P, Yu B, et al. The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: A systematic review and meta-analysis.[J/OL]. Oral oncology, 2020, 102: 104559.

Wan Y, Fu L H, Li C, et al. Conquering the Hypoxia Limitation for Photodynamic Therapy.[J/OL]. Advanced materials (Deerfield Beach, Fla.), 2021, 33(48): e2103978.

Tao Y, Liu Y, Dong Z, et al. Cellular Hypoxia Mitigation by Dandelion-like Nanoparticles for Synergistic Photodynamic Therapy of Oral Squamous Cell Carcinoma.[J/OL]. ACS applied materials & interfaces, 2022, 14(39): 44039-44053.

Downloads

Published

29-05-2024

Issue

Section

Articles

How to Cite

Liu, X., Zhao, X., Han, R., Liu, C., Gu, J., & Wu, W. (2024). Recent Advances in Photodynamic Therapy in the Treatment of Dental Diseases. International Journal of Biology and Life Sciences, 6(1), 44-47. https://doi.org/10.54097/2xds4124