Research Progress on the SDF-1/CXCR4 Axis in Cartilage Injury

Authors

  • Zunian He
  • Xiaoban Huang
  • Peng Ling
  • Yanggang Tang
  • Zhou Qin
  • Dinggui Lu

DOI:

https://doi.org/10.54097/ndn9gh19

Keywords:

SDF-1/CXCR4 Axis, Cartilage Repair, Stem Cell Migration, Tissue Regeneration

Abstract

The chemokine CXCL12, also known as stromal cell-derived factor 1 (SDF-1), is a small pro-inflammatory chemokine that primarily binds to CXC receptor 4 (CXCR4; CD184), serving as a major regulatory factor for cell transport and adhesion. When SDF-1 binds to CXCR4, it triggers intracellular signaling through several pathways that initiate processes such as chemotaxis, cell survival, proliferation, calcium influx, and gene transcription. The SDF-1/CXCR4 axis plays a crucial role in the development of bone marrow stem cells and the process of tissue regeneration. Repairing cartilage tissue necessitates a sufficient number of chondrocytes, making bone marrow mesenchymal stem cells particularly suitable for this purpose. This signaling pathway is essential for cartilage injury repair. It promotes stem cell migration and localization, regulates cell proliferation and differentiation, and inhibits inflammatory responses. This article reviews the current research advancements related to the SDF-1/CXCR4 axis in cartilage tissue repair.

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Published

28-09-2024

Issue

Vol. 7 No. 2 (2024)

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Articles

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