Chronic Periodontal Disease and Its Correlation with Carotid Intima-Media Thickness
DOI:
https://doi.org/10.54097/879m3664Keywords:
Chronic Periodontal Disease, Carotid Intima-media Thickness, Epidemiological Studies, AtherosclerosisAbstract
Chronic periodontal disease (periodontal disease, PD) is considered the sixth most prevalent disease affecting human health, with approximately 740 million people impacted globally. Over the past few decades, numerous studies have focused on the relationship between PD and cardiovascular diseases. Clinically, prior to the clear formation of atherosclerotic plaques, a subclinical indicator of increased carotid intima-media thickness (CIMT) is often observed. CIMT refers to the distance between the inner boundary of the carotid artery lumen and the outer boundary of the media layer, and it has been confirmed as an independent risk factor and predictive marker for coronary artery disease. As a potential risk factor, PD may lead to CIMT thickening through various mechanisms. This paper aims to explore the relationship between PD and CIMT, as well as the potential underlying mechanisms.
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[1] Tabari Z A, Hematzadeh S, Keshani F. IL29 expression in gingival tissues of chronic periodontitis and aggressive periodontitis patients: An immunohistochemical analysis[J]. Dent Res J (Isfahan), 2021,18:66.
[2] Boyer E, Martin B, Le Gall-David S, et al. Periodontal pathogens and clinical parameters in chronic periodontitis[J]. Mol Oral Microbiol, 2020,35(1):19-28.
[3] Araujo L L, Lourenco T, Colombo A. Periodontal disease severity is associated to pathogenic consortia comprising putative and candidate periodontal pathogens[J]. J Appl Oral Sci, 2023,31:e20220359.
[4] Harvey J D. Periodontal Microbiology[J]. Dent Clin North Am, 2017,61(2):253-269.
[5] Groeger S, Doman E, Chakraborty T, et al. Effects of Porphyromonas gingivalis infection on human gingival epithelial barrier function in vitro[J]. Eur J Oral Sci, 2010,118 (6): 582-589.
[6] Groeger S E, Meyle J. Epithelial barrier and oral bacterial infection[J]. Periodontol 2000, 2015,69(1):46-67.
[7] Takeuchi H, Sasaki N, Yamaga S, et al. Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1[J]. PLoS Pathog, 2019,15 (11): e1008124.
[8] Buduneli N. Implications of Antimicrobial Usage to Prevent Bacteremia for Periodontal Therapy[J]. Current oral health reports, 2018,5(1):19-25.
[9] Gallucci G, Turazza F M, Inno A, et al. Atherosclerosis and the Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside-Part 1[J]. Int J Mol Sci, 2024,25(8).
[10] Silvestre-Roig C, de Winther M P, Weber C, et al. Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies[J]. Circ Res, 2014,114(1):214-226.
[11] Sanz M, Marco D C A, Jepsen S, et al. Periodontitis and cardiovascular diseases: Consensus report[J]. J Clin Periodontol, 2020,47(3):268-288.
[12] Reyes L, Herrera D, Kozarov E, et al. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology[J]. J Clin Periodontol, 2013,40 Suppl 14:S30-S50.
[13] Ciarambino T, Crispino P, Minervini G, et al. Role of Helicobacter pylori Infection in Pathogenesis, Evolution, and Complication of Atherosclerotic Plaque[J]. Biomedicines, 2024,12(2).
[14] Lockhart P B, Bolger A F, Papapanou P N, et al. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association[J]. Circulation, 2012,125(20):2520-2544.
[15] Hansa G, Bhargava K, Bansal M, et al. Carotid intima-media thickness and coronary artery disease: an Indian perspective [J]. Asian Cardiovasc Thorac Ann, 2003,11(3):217-221.
[16] George J M, Bhat R, Pai K M, et al. The carotid intima media thickness: a predictor of the clincal coronary events[J]. J Clin Diagn Res, 2013,7(6):1082-1085.
[17] Persson J, Formgren J, Israelsson B, et al. Ultrasound-determined intima-media thickness and atherosclerosis. Direct and indirect validation[J]. Arterioscler Thromb, 1994, 14(2): 261-264.
[18] Pignoli P, Tremoli E, Poli A, et al. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging[J]. Circulation, 1986,74(6):1399-1406.
[19] Gariepy J, Massonneau M, Levenson J, et al. Evidence for in vivo carotid and femoral wall thickening in human hypertension. Groupe de Prevention Cardio-vasculaire en Medecine du Travail[J]. Hypertension, 1993,22(1):111-118.
[20] Barth J D, Roberts C K. Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?[J]. Eur Heart J, 2007,28(20):2552.
[21] Lorenz M W, Markus H S, Bots M L, et al. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis[J]. Circulation, 2007,115(4):459-467.
[22] Figuero E, Lindahl C, Marín M J, et al. Quantification of Periodontal Pathogens in Vascular, Blood, and Subgingival Samples From Patients With Peripheral Arterial Disease or Abdominal Aortic Aneurysms[J]. Journal of periodontology (1970), 2014,85(9):1182-1193.
[23] Rafieian-Kopaei M, Setorki M, Doudi M, et al. Atherosclerosis: process, indicators, risk factors and new hopes[J]. Int J Prev Med, 2014,5(8):927-946.
[24] Perry H M, Bender T P, McNamara C A. B cell subsets in atherosclerosis[J]. Front Immunol, 2012,3:373.
[25] Chung J W, Oh M J, Cho Y H, et al. Distinct Roles of Endothelial Dysfunction and Inflammation in Intracranial Atherosclerotic Stroke[J]. Eur Neurol, 2017,77(3-4):211-219.
[26] Fan J, Watanabe T. Inflammatory reactions in the pathogenesis of atherosclerosis[J]. J Atheroscler Thromb, 2003,10(2):63-71.
[27] Tapashetti R P, Guvva S, Patil S R, et al. C-reactive Protein as Predict of Increased Carotid Intima Media Thickness in Patients with Chronic Periodontitis[J]. J Int Oral Health, 2014, 6(4): 47-52.
[28] Demmer R T, Trinquart L, Zuk A, et al. The influence of anti-infective periodontal treatment on C-reactive protein: a systematic review and meta-analysis of randomized controlled trials [J]. PLoS One, 2013,8(10): e77441.
[29] Leite F, Nascimento G G, Peres K G, et al. Collider bias in the association of periodontitis and carotid intima-media thickness [J]. Community Dent Oral Epidemiol, 2020,48(4): 264-270.
[30] Vazquez-Reza M, Lopez-Dequidt I, Ouro A, et al. Periodontitis is associated with subclinical cerebral and carotid atherosclerosis in hypertensive patients: A cross-sectional study [J]. Clin Oral Investig, 2023,27(7):3489-3498.
[31] Beck J D, Elter J R, Heiss G, et al. Relationship of periodontal disease to carotid artery intima-media wall thickness: the atherosclerosis risk in communities (ARIC) study [J]. Arterioscler Thromb Vasc Biol, 2001,21(11):1816-1822.
[32] Liu Yujiao, Li Jieting, Ren Xiuyun, et al. Animal experiment on the effect of periodontal treatment on interleukin-6 and matrix metalloproteinases in periodontitis with arteriosclerosis. Chinese Journal of Stomatology, 2014, 49(3): 155-160.
[33] Iwamoto Y, Nishimura F, Soga Y, et al. Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis[J]. J Periodontol, 2003,74 (8): 1231-1236.
[34] Kudo C, Shin W S, Sasaki N, et al. Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study[J]. Odontology, 2018,106(3):316-327.
[35] Zhang Z, Liu D, Liu S, et al. The Role of Porphyromonas gingivalis Outer Membrane Vesicles in Periodontal Disease and Related Systemic Diseases[J]. Front Cell Infect Microbiol, 2020,10:585917.
[36] Kuramitsu H K, Qi M, Kang I C, et al. Role for periodontal bacteria in cardiovascular diseases[J]. Ann Periodontol, 2001,6 (1):41-47.
[37] Carter C J, France J, Crean S, et al. The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases[J]. Front Aging Neurosci, 2017,9:408.
[38] Ogrendik M, Kokino S, Ozdemir F, et al. Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis[J]. MedGenMed, 2005,7(2):2.
[39] Offenbacher S, Jared H L, O'Reilly P G, et al. Potential pathogenic mechanisms of periodontitis associated pregnancy complications [J]. Ann Periodontol, 1998,3(1):233-250.
[40] Wu Y, Wang Y, Du L, et al. The link between different infection forms of Porphyromonas gingivalis and acute myocardial infarction: a cross-sectional study[J]. BMC Oral Health, 2023,23(1):63.
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