Exploring the Research Progress of Traditional Chinese Medicine in Rheumatoid Arthritis based on the Nrf2/Keap1 Pathway

Ziyuan Yang; Chenxi Xue; Yangyang Liu; Bing Xu

doi:10.54097/fqwgr949

Authors

Ziyuan Yang
Chenxi Xue
Yangyang Liu
Bing Xu

DOI:

https://doi.org/10.54097/fqwgr949

Keywords:

Traditional Chinese Medicine, Rheumatoid Arthritis, Nrf2/Keap1 Signaling Pathway, Oxidative Stress

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitis and bone destruction. In recent years, the role of the Nrf2/Keap1 pathway in RA has received much attention. Research has shown that the Nrf2/Keap1 pathway plays an important role in RA by regulating oxidative stress and inflammatory response. Activation of Nrf2 can alleviate inflammation and bone destruction in RA, while overexpression of Keap1 may exacerbate RA symptoms. This article discusses the research progress of traditional Chinese medicine based on the Nrf2/Keap1 pathway in RA, including its molecular mechanism, role in the pathological process of RA, potential as a therapeutic target, and related drug development progress, providing new directions for drug development in the Nrf2/Keap1 pathway for RA treatment.

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References

[1] Rawla P. Cardiac and vascular complications in rheumatoid arthritis[J].Reumatologia, 2019,57(1):27-36.

[2] Xie X, Li H, Wang Y, etc. Therapeutic effects of gentiopicroside on adjuvant-induced arthritis by inhibiting inflammation and oxidative stress in rats[J]. IntImmunopharmacol, 2019,76:105840.

[3] Su X, Li T, Liu Z, et al. Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349. Free Radic Biol Med. 2018; 115:471-483.

[4] Liang Y, Xu X, Xu L, Iqbal Z, Ouyang K, Zhang H, Wen C, Duan L, Xia J. Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment. Theranostics. 2022 Jun 21;12(11):4866-4878.

[5] Ahmed SM, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: Pivotal roles in inflammation. Bba-Mol Basis Dis (2017) 1863(2):585–97.

[6] K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, M. Yamamoto, Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain, Genes Dev. 13 (1) (1999) 76e86.

[7] Hannon Barroeta P, O'Sullivan MJ, Zisterer DM. The role of the Nrf2/Gsh antioxidant system in cisplatin resistance in Malignant rhabdoid tumours. J Cancer Res Clin (2023) 149(11):8379–91.

[8] Wang Q, Botchway BOA, Zhang Y, Liu X. Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson's disease: A review. Biomed Pharmacother. 2022 Dec; 156:113848.

[9] Zheng Xin, Du Xiaozheng, Li Mengxin, etc. The correlation between Keap1-Nrf2/ARE signaling pathway and oxidative stress and rheumatoid arthritis [J]. Modern Immunology, 2020, 40 (04): 341-344.

[10] Sun Yue Exploring the mechanism of traditional Chinese medicine Xinfeng capsules in improving cardiovascular and pulmonary function in rheumatoid arthritis based on the Keap1-Nrf2/ARE signaling pathway [D]. Anhui University of Traditional Chinese Medicine, 2014.