The Correlation between the Risk of Cervical Cancer and the STK11 Genes rs12977689, rs60755851, and rs9282860

Yongchang Ling; Haisi Gan; Qingli Huang; Fengjuan Lin; Liling Xie

doi:10.54097/7pmdgf47

Authors

Yongchang Ling
Haisi Gan
Qingli Huang
Fengjuan Lin
Liling Xie

DOI:

https://doi.org/10.54097/7pmdgf47

Keywords:

STK11, SNP, Cervical Cancer, Disease Risk

Abstract

Objective Exploring the correlation between single nucleotide polymorphisms (SNPs) of the STK11 gene rs12977689, rs60755851, and rs9282860 and the risk of cervical cancer. Methods 350 patients with cervical cancer were selected as the cervical cancer group, and 351 normal women who underwent physical examinations during the same period were selected as the control group. Adopting imLDR ™ Multiple SNP typing technology was used to genotype the rs12977689, rs60755851, and rs9282860 loci in two groups of people, and analyze the correlation between these three SNP loci and the risk of cervical cancer. Results The genotype AA, allele A, and recessive model CA+CC of rs12977689 increase the risk of cervical cancer (OR=2.20, OR=1.35, OR=2.06); The rs9282860 allele T and dominant model CT+TT reduce the risk of cervical cancer (OR=0.72 and OR=0.70); However, there was no correlation between rs60755851 and cervical cancer (P>0.05). The above three SNPs were not associated with clinical pathological parameters of cervical cancer (P>0.05). The haplotypes A-A-C constructed at three loci have an increased risk of cervical cancer (OR=1.32), while haplotypes C-A-C and C-A-T have a reduced risk of cervical cancer (OR=0.75 and OR=072). Conclusion he STK11 gene rs12977689 may increase the risk of cervical cancer, while rs9282860 may reduce the risk of cervical cancer.

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