Research Progress in Tumor Treatment Based on the Theory of “Yang Transforms into Qi, Yin Forms into Substance”

Abstract

Tumors, quintessential examples of modern chronic and refractory diseases, are characterized by high incidence, mortality, and low cure rates, posing a significant challenge in global oncology. According to Traditional Chinese Medicine (TCM) theory, the pathogenesis of tumors is intricate and variable. TCM suggests that tumor development results from Yang Qi deficiency, which weakens the body’s ability to resist pathogens, combined with the congealing and binding of phlegm and blood stasis that form carcinogenic toxins. This pathological process aligns with the concept of “insufficient Yang transformation into Qi and excessive Yin constitution into form.” The fundamental oncogenic process involves systemic energy metabolism imbalance, the formation of the tumor microenvironment (TME), and uncontrolled cellular proliferation. Clinically, syndrome differentiation and treatment strategies are customized for different tumor progression stages, with restoring Yin-Yang balance as the primary goal and the dual aim of strengthening vital qi and eliminating pathogenic factors as the core of therapy. Early intervention with TCM during the precancerous phase to halt tumor progression, combined with early detection and treatment, not only improves clinical outcomes but also offers a new holistic approach to tumor prevention and management based on systems biology.