Microcirculation Detection Technology and its Application Progress in Septic Shock

Authors

  • Qian Ye
  • Haiyu Du
  • Jianhui Li

DOI:

https://doi.org/10.54097/mn393390

Keywords:

Septic Shock, Microcirculation Monitoring, Sublingual Microcirculation

Abstract

With the development of the theory of hemodynamic incoherence, the microcirculation has been found to be of great significance in the occurrence, development, and prognosis of septic shock. The key to multiple organ failure caused by septic shock is microcirculatory dysfunction, and organ failure is closely related to the mortality of septic shock. Therefore, microcirculation assessment has become a key focus in patients with septic shock. This article introduces the concept of microcirculation and the pathophysiology of microcirculatory disorders, reviews the current application status of commonly used clinical microcirculation monitoring indicators and techniques in septic shock, and points out the shortcomings and future prospects of microcirculation monitoring, aiming to provide new perspectives for the practice and scientific research of microcirculation monitoring in septic shock.

Downloads

Download data is not yet available.

References

[1] Cao Y, Chai YF, Deng Y, et al. Chinese guidelines for emergency treatment of sepsis/septic shock (2018). J Clin Emerg. 2018;19(9):567–588.

[2] NICE. Suspected sepsis: recognition, diagnosis and early management. 2016-2024.

[3] Ince C. Hemodynamic coherence and the rationale for monitoring the microcirculation. Crit Care. 2015;19(Suppl 3):S8.

[4] Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016;37(2):263–275.

[5] Lehr HA, Bittinger F, Kirkpatrick CJ. Microcirculatory dysfunction in sepsis: a pathogenetic basis for therapy? J Pathol. 2000;190(3):373–386.

[6] Jérémie J, Liles WC. Editorial: Endothelial activation and microcirculatory disorders in sepsis and critical illness. Front Med (Lausanne). 2023;9:01–02.

[7] Song J, Fang X, Zhou K, et al. Sepsis induced cardiac dysfunction and pathogenetic mechanisms (Review). Mol Med Rep. 2023;28(4):227.

[8] De Backer D, Ricottilli F, Ospina-Tascón GA. Septic shock: a microcirculation disease. Curr Opin Anaesthesiol. 2021;34(2):85–91.

[9] Yan Y, Wei J, Wu M, Ma CT, et al. Microcirculation monitoring and management in sepsis: starting from clinical practice. J Clin Emerg. 2024;(2):99–104.

[10] Wang SW, Zhu CQ. Progress in the application of microcirculation detection in the diagnosis and treatment of sepsis. J Clin Emerg. 2019;20(8):599–602.

[11] Xu JY, Yang Y. Progress in monitoring and treatment of microcirculatory disorders in shock patients. J Pract Shock. 2019;3(4):195–197.

[12] Dumas G, Lavillegrand JR, Joffre J, et al. Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters. Crit Care. 2019;23(1):211.

[13] Jog SA, Narasimhan VL, Rajhans PA, et al. Mottling in Septic Shock: Ethnicity and Skin Color Matter. Indian J Crit Care Med. 2023;27(12):902–909.

[14] Pulido-Pérez A, Bergón-Sendín M, Suárez-Fernández R, et al. Skin and sepsis: contribution of dermatology to a rapid diagnosis. Infection. 2021;49(4):617–629.

[15] Galbois A, Bige N, Pichereau C, Boelle PY, Baudel JL, Bourcier S, et al. Exploration of skin perfusion in cirrhotic patients with septic shock. J Hepatol. 2015;62(3):549–555.

[16] Shirley L, Fernández-Sarmiento J, Sofía B, et al. Capillary refill time in sepsis: A useful and easily accessible tool for evaluating perfusion in children. Front Pediatr. 2022; 10: 1035567.

[17] Kattan E, Bakker J, Estenssoro E, et al. Hemodynamic phenotype-based, capillary refill time-targeted resuscitation in early septic shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial study protocol. Rev Bras Ter Intensiva. 2022;34(1):96–106.

[18] Sekino M, Funaoka H, Sato S, et al. Association between macroscopic tongue ischemia and enterocyte injury and poor outcome in patients with septic shock: a preliminary observational study. Shock. 2018;50(5):530–537.

[19] Zeng XY, Liao XL, Chen Y, et al. Application and progress of microcirculation monitoring in patients with septic shock. Chin J Respir Crit Care Med. 2014;13(3):319–322.

[20] Wang SW, Guo J, Zhu CQ. Progress in microcirculation detection technology and its application in emergency and critical care medicine. J Clin Emerg. 2019;20(2):168–172.

[21] Zhao MY, Li A, Zhuang HZ, et al. Clinical significance of monitoring sublingual microcirculation for assessing severity and predicting prognosis in patients with severe sepsis. Chin Crit Care Med. 2012;24(3):158–161.

[22] Guo L, Chen H, Liu JM, et al. Analysis of the relationship between sublingual microcirculation changes and disease severity and prognosis in sepsis patients. J Pract Shock. 2022;6(4):204–207.

[23] Alexandros R, Laura Mareen S, Hans V, et al. Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care. 2019;23(1):260.

[24] Tang A, Shi Y, Dong Q, et al. Prognostic Value of Sublingual Microcirculation in Sepsis: A Systematic Review and Meta-analysis. J Intensive Care Med. 2024;39(12):1221–1230.

[25] Zhang LZ, Zhou M. Research progress on monitoring microcirculation status in shock patients. J Microcirc. 2020;30(3):65–68.

[26] Damiani E, Carsetti A, Casarotta E, et al. Microcirculation-guided resuscitation in sepsis: the next frontier? Front Med (Lausanne). 2023; 10:1212321.

[27] Chen H, Guo L, Liu JM, Liang ZQ, et al. Application study of sublingual microcirculation imaging system combined with ultrasound in volume assessment of septic shock. Chin J Med Res. 2021;19(34):4–8.

[28] Stephen PJ, Macdonald SP, Frances B, et al. Near-infrared spectroscopy to predict organ failure and outcome in sepsis: the Assessing Risk in Sepsis using a Tissue Oxygen Saturation (ARISTOS) study. Eur J Emerg Med. 2019;26(6): [Journal/Volume/Pages details from original reference assumed]

[29] Mendelson AA, Rajaram A, Bainbridge D, et al. Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study. J Clin Monit Comput. 2021;35(6):1453–1465.

[30] Barberio M, Benedicenti S, Pizzicannella M, et al. Intraoperative Guidance Using Hyperspectral Imaging: A Review for Surgeons. Diagnostics (Basel). 2021;11(11):2066.

[31] Dietrich M, Marx S, von der Forst M, et al. Bedside hyperspectral imaging indicates a microcirculatory sepsis pattern - an observational study. Microvasc Res. 2021;136: 104164.

[32] Dietrich M, Marx S, von der Forst M, et al. Hyperspectral imaging for perioperative monitoring of microcirculatory tissue oxygenation and tissue water content in pancreatic surgery - an observational clinical pilot study. Perioper Med (Lond). 2021;10(1):42.

[33] Holmer A, Tetschke F, Marotz J, et al. Oxygenation and perfusion monitoring with a hyperspectral camera system for chemical based tissue analysis of skin and organs. Physiol Meas. 2016;37(11):2064–2078.

[34] Dietrich M, Özdemir B, Gruneberg D, et al. Hyperspectral Imaging for the Evaluation of Microcirculatory Tissue Oxygenation and Perfusion Quality in Haemorrhagic Shock: A Porcine Study. Biomedicines. 2021;9(12):1829.

[35] Corradi F, Via G, Tavazzi G. What's new in ultrasound-based assessment of organ perfusion in the critically ill: expanding the bedside clinical monitoring window for hypoperfusion in shock. Intensive Care Med. 2020;46(4):775–779.

[36] Watchorn J, Huang D, Bramham K, et al. Decreased renal cortical perfusion, independent of changes in renal blood flow and sublingual microcirculatory impairment, is associated with the severity of acute kidney injury in patients with septic shock. Crit Care. 2022;26(1):261.

[37] Evans L, Rhodes A, Alhazzani W, Antonelli M, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247.

[38] Johansson PI, Soe-Jensen P, Bestle MH, et al. Prostacyclin in intubated patients with COVID-19 and severe endotheliopathy: a multicenter, randomized clinical trial. Am J Respir Crit Care Med. 2022;205(3):324–329.

[39] Lavillegrand JR, Raia L, Urbina T, et al. Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients. Crit Care. 2022;26(1):25.

[40] Legrand M, Oufella HA, De Backer D, et al. The I-MICRO trial, Ilomedin for treatment of septic shock with persistent microperfusion defects: a double-blind, randomized controlled trial-study protocol for a randomized controlled trial. Trials. 2020;21(1):601.

[41] Ince C. Physiology and technology for the ICU in vivo. Crit Care. 2019;23(Suppl 1):126.

[42] De Backer D, Verdant C, Chierego M, et al. Effects of drotecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med. 2006;34(7):1918–1924.

[43] Donati A, Damiani E, Botticelli L, et al. The aPC treatment improves microcirculation in severe sepsis/septic shock syndrome. BMC Anesthesiol. 2013; 13:25.

Downloads

Published

29-10-2025

Issue

Section

Articles

How to Cite

Ye, Q., Du, H., & Li , J. (2025). Microcirculation Detection Technology and its Application Progress in Septic Shock. International Journal of Biology and Life Sciences, 12(2), 54-58. https://doi.org/10.54097/mn393390