Advances in the Application of Berberine for Neurological Disorders

Haihong Xu; Jiaxian Liang; Jun Li; Jianwen Zhi; Bo Ning

doi:10.54097/tbd9mj42

Authors

Haihong Xu
Jiaxian Liang
Jun Li
Jianwen Zhi
Bo Ning

DOI:

https://doi.org/10.54097/tbd9mj42

Keywords:

Application Progress, Berberine, Mechanism of Action, Neurological Disorders

Abstract

Berberine (BBR), a natural isoquinoline alkaloid, has demonstrated broad potential in treating neurological disorders in recent years. Its mechanisms encompass antioxidant stress, anti-neuroinflammation, inhibition of neuronal apoptosis, and regulation of neurotransmitter levels. However, challenges remain, including low oral bioavailability and safety concerns such as gastrointestinal discomfort and allergic reactions. Therefore, this systematic review examines the mechanism studies and therapeutic advances of BBR in neurological disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD), aiming to provide references for neuroprotective drug development.

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References

[1] Xue Jian, Ma Wei, Xu Shiyi, et al. Research progress on the active ingredients of red peony root in treating central nervous system diseases [J]. Chinese Herbal Medicines, 2024, 55(19):6806-6819.

[2] Wu Ziwen, Zhang Li. Epidemiological Characteristics of Chronic Neurological Diseases in the Elderly [J]. Practical Geriatrics, 2025, 39(3):223-227.

[3] Yang Hanbing, Shi Jiawei, Hou Yue, et al. Distribution of PDE4 in the brain and its role in neurodegenerative diseases [J]. Journal of Shandong First Medical University (Shandong Academy of Medical Sciences), 2023, 44(3): 186-190.

[4] Guo Fanyi, Wang Ruyu, Du Yifei, et al. Research progress on the correlation between berberine, oral microbiota, and systemic diseases [J]. Journal of Stomatology, 2024, 44(10):791-795.

[5] Hu Xi, Zhang Ying, Li Kun, et al. Clinical pharmacological effects of berberine, the main component of Coptis chinensis: An analysis [J]. Modern Distance Education of Chinese Medicine, 2021, 19(24): 203-205.

[6] WANG Y, TONG Q,MA S R,et al. Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota[J]. Signal Transduct Target Ther, 2021,6(1):77.

[7] Ouyang Haiyan, Chen Ouying, Zhang Huiping, et al. Study on the effects of berberine on oxidative stress/inflammatory response and angiogenesis in rats with ischemic cerebral infarction [J]. Advances in Modern Biomedicine, 2022, 22(23): 4417-4422.

[8] Mou Lei, Gao Daili, Wang Lizhen, et al. Study on the Anti-Parkinson's Disease Activity and Mechanism of Action of Berberine Derivative 9-OH Berberine [J]. Chinese Journal of Hospital Pharmacy, 2022, 42(09):884-888.

[9] TSENG H C,WANG M H,FANG C H,et al. Neuroprotective potentials of berberine in rotenone-induced Parkinson’s diseaselike motor symptoms in rats[J]. Brain Sci,2024,14 (6): 596.

[10] Ao Shengfu, Zhong Penggui. Progress in research on alkaloid treatment of neuropathic pain based on inflammatory signaling pathways [J]. Modern Drugs and Clinical, 2022, 37(5):1162-1168.

[11] ZENG Q,DENG H,LI Y,et al. Berberine directly targets the NEK7 protein to block the NEK7-NLRP3 interaction and exert anti-inflammatory activity[J]. Journal of medicinal chemistry, 2021, 64(1):768-781.

[12] Wu Y,Chen Q J, Wen B,et al. Berberine reduces Aβ42 deposition and tau hyperphosphorylation via ameliorating endoplasmic reticulum stress [J]. Front Pharmacol, 2021,12: 640758.

[13] Tian Yue, Wang Qi, Luo Yumin. Research Progress on Berberine-Mediated Anti-Cerebral Ischemia Apoptosis Pathways [J]. Practical Drugs and Clinical, 2021, 24(5):461-465.

[14] Meng Weiwei, Ma Ruihua, Yang Huihui, et al. Effects of Adjunctive Berberine Hydrochloride on Anxiety Symptoms and Sleep Quality in Patients with Depression [J]. Neurological Diseases and Mental Health, 2024, 24(7):464-471.Lin L,Li C, Zhang DY,et al. Synergic effects of berberine and curcumin on improving cognitive function in an Alzheimer's disease mouse model[J]. Neurochem Res,2020,45(5):1130-1141.

[15] Chen Y, Chen YL, Liang YB,et al. Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance[J]. Biomed Pharmacother,2020,121:109670.

[16] Wang L Z, Sheng W L,Tan Z S,et al. Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for bioimaging experiments[J]. Comp Biochem Physiol C Toxicol Pharmacol,2021,249:109151.

[17] Wang Y, Tong Q,Ma S R,et al. Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota [J]. Signal Transduct Target Ther, 2021,6(1):77.

[18] Tan Huiqi, Yang Liping, Xie Liting, et al. Effects of Berberine on NEK7/NLRP3 Pathway in Brain Tissue with Ischemia-Reperfusion Injury[J]. Journal of Hunan Normal University (Medical Edition), 2024, 21(05):6-12.

[19] Ma Shijiang, Guo Yanjie, Zhang Linli, et al. Investigation of the Mechanism of Berberine in Treating Ischemic Stroke Based on Network Pharmacology [J]. Chinese Journal of Modern Chinese Medicine, 2022, 24(02): 284-293.

[20] Liang Zifei, Wu Anshi, Shen Wenzhen, et al. Study on the effect of berberine hydrochloride on trigeminal neuralgia in rats based on the NLRP3 inflammasome signaling pathway [J]. Chinese Journal of Hospital Pharmacy Evaluation and Analysis, 2021, 21(6):658-662.

[21] Yuan Yuming, Xu Jingxin, Zhang Jingqing. Pharmacokinetics and bioequivalence study of berberine hydrochloride lipid nanoparticles[J]. Chinese Journal of Clinical Pharmacology, 2022, 38(11):1251-1254.

[22] Marino M, Gardana C, Scialpi A, et al. An in vitro approach to study the absorption of a new oral formulation of berberine[J].PharmaNutrition, 2021, 18:100279.

[23] Liang Wantian, Tang Liangqiu, Chen Jinfeng, et al. The therapeutic effect of berberine on coronary unstable plaques after percutaneous coronary intervention in acute myocardial infarction [J]. Chinese Medicine, 2021, 16(1):28-32.

[24] Wang Jing, Hu Jinhua, Wang Jinghua, et al. Observation on the Effect of Berberine Hydrochloride Combined with Metformin in the Treatment of Type 2 Diabetes [J]. Chinese Journal of Diabetes, 2022, 30(5):353-357.