Elevated Risk of Breast Cancer in Blood Type a Female Individuals in Hubei Province, China
DOI:
https://doi.org/10.54097/a20k8q87Keywords:
Breast Cancer, ABO Blood Group, CA153, MastitisAbstract
The relationship between the ABO blood group and the risk of female breast cancer remains a subject of ongoing debate, with differing conclusions likely attributable to variations in ethnicity and region of study populations. To elucidate the correlation between breast cancer risk and the ABO blood group in Hubei Province, China, we conducted a comprehensive analysis involving 4,060 female breast cancer patients, 10,522 breast mastitis patients, and 1621 patients who progressed from mastitis to breast cancer, all admitted to “Hubei Provincial Cancer Hospital” between 2017 and 2024. The distribution of both ABO blood groups and CA153 levels among these patients was examined. Our results show that women with blood group A have a significantly higher risk of mastitis and breast cancer, with the highest risk for progression from mastitis to cancer. In contrast, women with blood group O demonstrated the lowest incidence of mastitis, breast cancer, and progression from mastitis to breast cancer. Notably, CA153 levels were more likely to normalize in women with blood group A as treatment progressed. These results suggest that women with blood group A in Hubei Province face a heightened risk of breast cancer but experience the best treatment outcomes, whereas those with blood group O have a lower risk yet may encounter greater treatment challenges. Our findings provide more evidence for the correlation between the ABO blood group and breast cancer risk in the Han Chinese population; meanwhile, we propose the concept of setting different CA153 thresholds according to the ABO blood group.
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