The Application Value of Tumor-Educated Platelet RNA in Hepatocellular Carcinoma Patients

Jie Lv; Beibei Zhu; Jingwen Liu; Hongke Zhou

doi:10.54097/h8rrcd56

Authors

Jie Lv
Beibei Zhu
Jingwen Liu
Hongke Zhou

DOI:

https://doi.org/10.54097/h8rrcd56

Keywords:

Hepatocellular Carcinoma, Tumor-educated Platelets, Liquid Biopsy, Diagnosis, RNA

Abstract

Hepatocellular carcinoma (HCC), a highly prevalent malignant tumor worldwide, exhibits insidious onset and rapid progression. Patients are often diagnosed at an advanced stage, missing the optimal treatment window. In liquid biopsy, Tumor-Educated Platelets (TEPs) reveal that tumors can alter platelet RNA expression profiles through multiple mechanisms, positioning them as novel sources of biomarkers for tumor diagnosis. This review systematically elucidates the biological characteristics of TEPs in HCC development and their RNA expression profiles, summarizing the diagnostic value of TEPs RNA in early HCC screening, pathological classification, and treatment monitoring, thereby providing theoretical reference for non-invasive HCC diagnosis.

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