A Review of Emerging Neuromodulation Therapies for Alzheimer’s Disease

Chenyu Zhou

doi:10.54097/d3pa9y94

Authors

Chenyu Zhou

DOI:

https://doi.org/10.54097/d3pa9y94

Keywords:

Alzheimer’s Disease, Neuromodulation Therapies, Noninvasive Physical Stimulation, Gamma Band Oscillation

Abstract

Alzheimer’s disease (AD) is the most common form of dementia, primarily affecting the elderly. It is currently understood to be driven by the accumulation of β-amyloid (Aβ) plaques and tau protein tangles in the brain, leading to neuronal death. Currently, the most common and well-established treatment remains pharmacotherapy, years of clinical trials have demonstrated its efficacy, yet its high cost cannot be overlooked. Nowadays, with the advancement of physical modulation technologies, an increasing array of emerging techniques are steadily expanding their applications into the field of neuromodulation, including transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), optical neuromodulation technologies, transcranial focused ultrasound (tFUS), gamma band oscillation stimulation technology. This review discusses development status and application fields of different techniques, containing clarifying the working principles, comparing advantages and disadvantages and provide an outlook on the treatment of Alzheimer’s disease.

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