The Relative Impact of Maternal and Paternal Depression History on Externalizing Behaviors and Psychopathology Susceptibility in Children

Authors

  • Yansong Lu

DOI:

https://doi.org/10.54097/5g73v632

Keywords:

Parental Depression, Intergenerational Transmission, Propensity Score Matching, P-factor

Abstract

Adolescent depression is a major global public health issue, closely linked to familial risk. To elucidate the intergenerational transmission of depression, this study utilized baseline data from the Adolescent Brain Cognitive Development (ABCD) Study in the United States. Employing propensity score matching to control for confounders, we quantified the impact of parental depression history on behavioral problems and susceptibility to mental disorders (p-factor) in children aged 9-11. Results from the successfully matched sample showed that both maternal and paternal depression histories significantly increased adolescents' externalizing behavioral problems and general susceptibility to mental disorders. Notably, the average effect size for maternal depression history (Cohen's d = 35.56%) was significantly greater than that for paternal history (20.95%). This indicates that the influence of familial depression history is broad, extending beyond depressive symptoms to elevate overall vulnerability to various mental health problems. This study quantified the differential effects of maternal versus paternal depression history on adolescent mental health and specified their respective effect sizes on the general psychopathology factor (p-factor) in adolescents.

Downloads

Download data is not yet available.

References

[1] Friedrich MJ. Depression is the leading cause of disability around the world. JAMA. 2017 Apr 18;317(15):1517.

[2] Shorey S, Ng ED, Wong CHJ. Global prevalence of depression and elevated depressive symptoms among adolescents: a systematic review and meta-analysis. Br J Clin Psychol. 2022 June;61(2):287–305.

[3] Hankin BL, Abramson LY, Moffitt TE, Silva PA, McGee R, Angell KE. Development of depression from preadolescence to young adulthood: emerging gender differences in a 10-year longitudinal study. J Abnorm Psychol. 1998 Feb;107(1):128–40.

[4] Rao U, Chen LA. Characteristics, correlates, and outcomes of childhood and adolescent depressive disorders. Dialogues Clin Neurosci. 2009;11(1):45–62.

[5] van Dijk MT, Murphy E, Posner JE, Talati A, Weissman MM. Association of multigenerational family history of depression with lifetime depressive and other psychiatric disorders in children: results from the adolescent brain cognitive development (ABCD) study. JAMA psychiatry. 2021 July 1;78 (7):778–87.

[6] Weissman MM, Wickramaratne P, Gameroff MJ, Warner V, Pilowsky D, Kohad RG, et al. Offspring of depressed parents: 30 years later. Am J Psychiatry. 2016 Oct 1;173(10):1024–32.

[7] Casey BJ, Cannonier T, Conley MI, Cohen AO, Barch DM, Heitzeg MM, et al. The adolescent brain cognitive development (ABCD) study: imaging acquisition across 21 sites. Dev Cognit Neurosci. 2018 Aug; 32:43–54.

[8] Stewart LC, Asadi S, Rodriguez-Seijas C, Wilson S, Michelini G, Kotov R, et al. Measurement invariance of the child behavior checklist (CBCL) across race/ethnicity and sex in the adolescent brain and cognitive development (ABCD) study. Psychol Assess. 2024 Aug;36(8):441–51.

[9] Buuren S van, Groothuis-Oudshoorn K. mice: multivariate imputation by chained equations in R. J Stat Softw. 2011 Dec 12; 45:1–67.

[10] Hill ED, Kashyap P, Raffanello E, Wang Y, Moffitt TE, Caspi A, et al. Prediction of mental health risk in adolescents. Nat Med. 2025 June;31(6):1840–6.

[11] Yang FN, Xie W, Wang Z. Effects of sleep duration on neurocognitive development in U.S. early adolescents: a propensity score matched, longitudinal, observational study. Lancet, Child adolesc health. 2022 July 29;S2352-4642(22) 00188-2.

Downloads

Published

25-12-2025

Issue

Section

Articles

How to Cite

Lu, Y. (2025). The Relative Impact of Maternal and Paternal Depression History on Externalizing Behaviors and Psychopathology Susceptibility in Children. International Journal of Biology and Life Sciences, 12(3), 199-203. https://doi.org/10.54097/5g73v632