Research Progress on the Relationship between Triglyceride-Glucose Body Mass Index and Cardiovascular Disease Risk

Authors

  • Xianglin Chen
  • Liting Wu
  • Shenghao Fu
  • Anxin Liu
  • Shiwen Feng
  • Chengcai Chen

DOI:

https://doi.org/10.54097/t3c31072

Keywords:

Triglycerides, Glucose, Body Mass Index (TyG-BMI), Cardiovascular Disease, Risk Assessment

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of disability and mortality worldwide. Early identification of high-risk populations and implementation of effective interventions are crucial for reducing their incidence and mortality risks. Traditional risk assessment indicators have certain limitations, while the triglyceride-glucose body mass index (TG-GBMI), as a relatively novel metabolic syndrome evaluation metric in recent years, integrates the triglyceride-glucose index with body mass index, offering advantages such as simple calculation and good reproducibility. This article systematically reviews the research on the TG-GBMI and its correlation with major CVDs, including coronary heart disease (CHD), hypertension, heart failure, and stroke, aiming to provide references for early prevention, risk stratification, and clinical intervention of CVDs.

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References

[1] Luo Pingping, Liu Qun, Huang Liwen. Predictive value of triglyceride-glucose body mass index (TyG-BMI) for severity of hyperlipidemic acute pancreatitis [J]. Journal of Clinical Hepatology and Biliary Diseases, 2024,40(8):1661-1665. DOI: 10.12449/ JCH240824.

[2] Shao Liyan, Li Yulong, Fu Shihui, et al. Study on the relationship between triglyceride-glucose index and acute myocardial infarction in the elderly [J]. Chinese Journal of Health Care Medicine, 2024,26(4):396-398.

[3] Zhou X, Liu R, Liu Y, et al. Predictive value of TyG index for adverse cardiovascular events in patients with acute myocardial infarction[J]. Armed Police Medical Journal, 2025,36(1):25-29. DOI: 10.3969/j.issn.1004-3594.2025.01.006.

[4] Pan Yaojia, Wang Weiqiang, Yi Weizhuo, etal. Relationship between triglyceride-glucose product (TyG) index and high-risk cardiovascular disease in middle-aged obese residents of different genders in Anhui Province [J]. China General Practice, 2023(1).

[5] Wang Yuning, Yu Hang, Hu Xiaoqing. Research progress of TyG index in cardiovascular diseases [J]. Clinical Medicine Progress, 2024,14(3):1788-1794. DOI: 10.12677/acm. 2024. 143908.

[6] Guo Zhixia, Xin Mankun, Duan Wenwen, et al. Study on the Correlation and Predictive Value of TyG Index with Major Adverse Cardiovascular Events in Elderly Patients with Acute Coronary Syndrome[J]. China Medical Guide, 2025,22(1):130-135.

[7] Ma YME. Predictive value of TyG index for cardiovascular disease risk in young and middle-aged populations [D]. Ningxia Medical University, 2025.

[8] Pan Y, Liu ST, Gu HY, et al. Genetic risk of insulin resistance and the effect of triglyceride-glucose index on cardiovascular disease risk [J]. Chinese Journal of Geriatrics, 2025,44(05): 643-649. DOI: 10.3760/cma.j.issn.0254-9026.2025.05.012.

[9] Zeng Ruihuang, Wang Xiaolin, Yuan Ning, et al. Predictive value of TyG index for MACCE after ischemic stroke [J]. Journal of Cardiovascular Rehabilitation Medicine, 2023,32(2): 119-123.

[10] Li X. Correlation study between triglyceride-glucose (TyG) index and carotid atherosclerotic plaques [J]. Chinese Journal of Science and Technology (Full-text Edition), Medicine & Health, 2023(011):000.

[11] Zhang MW, Xu CY, Duan Y, et al. Evaluation of prognosis in patients with acute myocardial infarction using the TyG index[J]. 2021. DOI: 10.3969/j.issn.1674-4055.2021.04.28.

[12] Luo Weigang, Liu Wanhui, Yin Yuanyuan, et al. Research progress on triglyceride-glucose index and ischemic stroke [J]. Journal of Stroke and Neurological Diseases, 2023,40 (12): 1140-1144. DOI: 10.19845/j. cnki. zfysjjbzz.2 023.0244.

[13] Zhu X, Chen J, Liu XL, etal. A retrospective cohort study on the triglyceride-glucose product index and the progression of atherosclerosis[J]. Journal of Central South University (Medical Edition), 2024,49(6):951-960.

[14] Shi Liping, Wang Wenxia, Zheng Liang, et al. Predictive value of TyG index for cardiovascular disease and metabolic syndrome in elderly community residents [J]. Journal of Tongji University (Medical Edition), 2023,44(6):841-847.

[15] Qin Mengzhen, Dong Yuying, Wang Haiyan, et al. The predictive value of TyG index combined with glomerular filtration rate for major adverse cardiovascular events in patients with acute ischemic stroke[J]. China Medical Guide, 2025(11).

[16] Chang JQ. Research progress on TyG index and its related derived indices in cardiovascular diseases [J]. Clinical Personalized Medicine, 2025,4(3):8. DOI: 10.12677/jcpm. 2025. 43322.

[17] Zhao YY, Li XS. Correlation study between TyG index and atherosclerotic cardiovascular disease (ASCVD) [J]. Clinical Medicine Progress, 2025,15(1):1092-1099. DOI: 10.12677/ acm. 2025.151146.

[18] Wang Wenjuan. Clinical study on TyG index and high-risk cardiovascular disease in elderly patients [D]. Gansu University of Chinese Medicine, 2023.

[19] Zhou X. Research progress on the relationship between triglyceride-glucose index and adverse prognosis in patients with coronary heart disease [J]. Clinical Medical Progress, 2025, 15(5):6. DOI: 10.12677/acm.2025.1551428.

[20] Jia Haiyan, Zhang Weifeng, Jia Xinwei, Jie Junmin, Wang Yanfei, Zhang Jing, Wu Yanmin, Zu Yugang, Liu Sha, Liu Yi, Wang Xiaowei. Predictive value of triglyceride-glucose index for major adverse cardiac events (MACE) in patients with acute myocardial infarction [J].2024.

[21] Ma X ,Chu H ,Sun Y , [21]Ma X ,Chu H ,Sun Y , et al. The effect of hsCRP on TyG index-associated cardiovascular risk in patients with acute coronary syndrome undergoing PCI [J]. Scientific Reports,2024,14(1):18083-18083.

[22] Cancan C ,Lin L ,Yitian Q , et al. Joint association of TyG index and high sensitivity C-reactive protein with cardiovascular disease: a national cohort study [J]. Cardiovascular Diabetology,2024,23(1):

[23] Yao Y ,Wang B ,Geng T , [23]Yao Y ,Wang B ,Geng T , et al. The association between TyG and all-cause/non-cardiovascular mortality in general patients with type 2 diabetes mellitus is modified by age: results from the cohort study of NHANES 1999-2018.[J].Cardiovascular diabetology, 2024, 23(1):43-43.

[24] Chang S ,Zeyu W ,Zhen Q , [24]Chang S ,Zeyu W ,Zhen Q , et al. TYG Index as a Novel Predictor of Clinical Outcomes in Advanced Chronic Heart Failure with Renal Dysfunction Patients.[J].Clinical interventions in aging,2024,19639-654.

[25] Jie P ,Linyan Q ,Xiaoru C , [25]Jie P ,Linyan Q ,Xiaoru C , et al. TyG index is a predictor of all-cause mortality during the long-term follow-up in middle-aged and elderly with hypertension.[J].Clinical and experimental hypertension (New York, N.Y. : 1993),2023,45(1):2272581-2272581.

[26] Özkan Uğur,Gürdoğan Muhammet. TyG index as a predictor of spontaneous coronary artery dissection in young women. [J]. Postgraduate medicine,2023,135(7):669-675.

[27] Weihua C ,Shan D ,Jiabin T , [27]Weihua C ,Shan D ,Jiabin T , et al. Association between the insulin resistance marker TyG index and subsequent adverse long-term cardiovascular events in young and middle-aged US adults based on obesity status.[J].Lipids in health and disease,2023,22(1):65-65.

[28] Faqir I M ,Xue B ,M. P N , et al. Triglyceride-glucose (TyG) index is a predictor of arterial stiffness, incidence of diabetes, cardiovascular disease, and all-cause and cardiovascular mortality: A longitudinal two-cohort analysis[J].Frontiers in Cardiovascular Medicine,2023,91035105-1035105.

[29] Ahmed A ,Ali H A . TG/HDL, Non-HDL, and TyG index as predictive parameters for CVDs in uncontrolled diabetic patients better than LDL-C and LDL/HDL ratio[J]. Research Journal of Pharmacy and Technology,2022,15(12):5490-5494.

[30] Zihan W ,Tianyi L ,Liubo Z , [30]Zihan W ,Tianyi L ,Liubo Z , et al. Predictive value of the TyG index and rheumatoid factor for cardiovascular disease risk in a rheumatoid arthritis population: data from a survey of 418 patients[J].Lipids in Health and Disease,2022,21(1):122-122.

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Published

27-01-2026

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