Application of Epimedium in Treatment of Erectile Dysfunction

Chengrui Ye

doi:10.54097/rpzj2s83

Authors

Chengrui Ye

DOI:

https://doi.org/10.54097/rpzj2s83

Keywords:

Erectile Dysfunction, Epimedium, Traditional Chinese Medicine.

Abstract

Erectile Dysfunction (ED), means that Penis cannot reach or keep Erecting enough in sex to finish satisfactory sexual intercourse, is a common health issue of males. The prevalence of ED increase with the increasing of age of males. This review article first presents prevalence data for ED among Chinese males, noting that modern medical treatments (PDE5 inhibitors, vacuum erection devices) carry side effects or discomfort. It then analyses ED mechanisms from both Chinese and Western medical perspectives: Traditional Chinese Medicine (TCM) centers on "malnourished/lax tendons", while modern medicine categorizes it as organic ED, psychogenic ED, or a combination of both. Subsequently, it details the traditional application of Epimedium, documented in the Divine Farmer's Classic of Materia Medica for treating "impotence," its key active constituents (quercetin, kaempferol, icariin), and the pathways through which it improves ED. It also presents evidence-based clinical evidence of its use in formulations or proprietary Chinese medicines for ED intervention. Finally, it analyses current research limitations (lack of high-quality clinical evidence, risks of hepatic injury and endocrine effects, poor water solubility of icariin) and proposes future directions: deepening mechanism research, strictly controlling dosage and standardizing processing techniques, and leveraging nanotechnology to enhance quality, thereby providing reference for its clinical translation.

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References

[1] Chen Weihong, Yang Ling, Chen Yue, et al. Meta-analysis of the Prevalence of Male Erectile Dysfunction in China [J]. Chinese Journal of Sexology, 2024, 33 (7): 12-18.

[2] Carlson, Elizabeth A. "Agency for healthcare research and quality (AHRQ) web site." Orthopaedic Nursing 27.4 (2008): 258-259.

[3] Matsui H, Sopko NA, Hannan JL, Bivalacqua TJ. Pathophysiology of erectile dysfunction. Curr Drug Targets. 2015; 16 (5):411-9.

[4] Tang Yuxin, Jiang Xianzhen, Tang Jin, et al. Etiological analysis of 1160 cases of penile erectile dysfunction [J]. Chinese Journal of Andrology, 2005, 19 (1): 22-24.

[5] Zhang Jiaying, Sun Qing. Mechanism of Action of Epimedium in Treating Erectile Dysfunction Based on Network Pharmacology [J]. Guangdong Chemical Industry, 2023, 50 (12): 60-66.

[6] Liu Tongzu, Hu Liquan, Zheng Xinmin, et al. Effects of Androgens on the Expression of Vascular Endothelial Growth Factor and Its Receptors in Rat Penile Tissue [J]. Chinese Journal of Experimental Surgery, 2003, (01): 68-69+100.

[7] Shindel AW, Xin ZC, Lin G, et al. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. J Sex Med. 2010 Apr; 7 (4 Pt 1): 1518-28.

[8] Zhang J, Li S, Li S, Zhang S, et al. Effect of icariside II and metformin on penile erectile function, glucose metabolism, reaction oxygen species, superoxide dismutase, and mitochondrial autophagy in type 2 diabetic rats with erectile dysfunction. Transl Androl Urol. 2020 Apr; 9 (2): 355-366.

[9] Mu Junjie, Feng Jing, Zhang Wensong, et al. Icariin mediates the Nrf2/HO-1 signalling pathway to alleviate renal ischaemia-reperfusion injury and oxidative stress in rats [J]. Journal of Anhui Medical University, 2021, 56 (3): 449-453, 457.

[10] Yang X, Cui Y, Zhou Z, Zhao H, Zhang Y. Analysis of pharmacological mechanisms of Yinyanghuo as treatment of erectile dysfunction with network pharmacology-based strategy. Andrologia. 2021 Mar; 53 (2): e13943.

[11] Zhang Sizheng, Su Liang, Luo Chenglong, et al. Efficacy evaluation of compound Xuanju capsules in treating male erectile dysfunction: A meta-analysis of randomised controlled trials [J]. Chinese Journal of Sexology, 2023, 32 (3): 118-126.

[12] Huang Yanping, Wu Zhengmu, Yang Nianqin, et al. Multicentre Clinical Efficacy Observation of Shanhaidan Granules Combined with Tadalafil for the Treatment of Erectile Dysfunction [J]. Chinese Journal of Andrology, 2021, 27 (9): 819-824.

[13] Lin, M. Y., Liu, Y. F., Lin, Q., et al. Meta-analysis of the efficacy of Liver-Soothing and Yang-Enhancing Capsules for male erectile dysfunction [J]. Straits Pharmaceutical Journal, 2022, 34 (11): 119-123.

[14] Zhang Yue, Wang Jiayi, Liu Huimin, et al. Research Progress on the Effects of Main Chemical Components of Epimedium and Its Preparations on Liver Injury [J]. Chinese Herbal Medicine, 2023, 54 (21): 7213-7221.

[15] Meng Hudie, Chen Yuqing, Gao Yuqin. Research progress on the interaction between four major blood-penetrating components of "Erxian" and oestrogen receptors [J]. Advances in Clinical Medicine, 2024, 14 (7): 6-11. D.

[16] Wang Na, Zhang Kanghuai, Mao Wenbin, et al. Solubility-based investigation of solubilising effects of different cyclodextrins on icariin [J]. Chinese Pharmacist, 2020, 23 (2): 260-263.

[17] South China Botanical Garden Achieves Progress in Stabilisation Research of Icariin. South China Botanical Garden, Chinese Academy of Sciences, 2025.01, http://www.scbg.ac.cn/kx/kyjz/202501/t20250126_7523972.html?push_animated=1&webview_progress_bar=1&show_loading=0&theme=light.