Wood Vinegar Promote Wound Healing by Regulates p38 MAPK Signal Pathway

Zhongwei Lu; Huicong Shang; Zaoshi Wang; Wenhui Wu; Qing Dong; Jianqi Gu

doi:10.54097/99k0ps90

Authors

Zhongwei Lu
Huicong Shang
Zaoshi Wang
Wenhui Wu
Qing Dong
Jianqi Gu

DOI:

https://doi.org/10.54097/99k0ps90

Keywords:

Plant Vinegar, p38 MAPK, Diabetic Wounds

Abstract

Objective: To investigate the mechanism by which wood vinegar regulates the expression of p38 MAPK signaling pathway and promote wound healing in diabetic rats. Methods: The wound model of diabetic rats was established, and different corresponding interventions were given to study the effect of wood vinegar on the wound healing of diabetic rats. Results: The healing rate of the wound was 24.12±1.01% on the third day after operation, which was significantly higher than that of the model group (8.21±0.69% (P<0.05), On the 6th and 9th days, the healing rates of the wood vinegar group (37.38±1.17%, 59.14±1.11%) continued to be higher than those of the other groups, which was statistically significant (P<0.05). On the 12th day, the healing rate of wood vinegar group reached 88.84±1.60%, which was significantly higher than that of the model group (P<0.05) of 58.36±1.85%. On the 15th day of the experimental endpoint, healing rate was 93.63±1.25%, while the aloe vera gel group was 87.77±1.51%, while the model group was only 68.21±0.53% (P<0.05); TNF-α content: The results of Elisa showed that the expression intensity of TNF-α, an inflammatory factor, in the four groups of rats showed an overall trend of the model group> blank group> AG group> WV group at 15 days; p38MAPK expression intensity: Western-blot Western blot showed that the expression intensity of p38 MAPK in the wound of the model group was the same as that of the wood vinegar group (P<0.05) and the aloe vera gel group (P<0.001), and the content of p38 MAPK was the lowest in the wood vinegar group. Conclusion: Plant-derived wood vinegar can reduce the inflammatory response of wounds and promote wound healing in diabetic rats by regulating the expression intensity of p38 MAPK signaling pathway.

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References

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