From α-Synuclein Pathology to Practice: Understanding Parkinson's Disease Through Luk et al. (2012)

Abstract

Parkinson's disease (PD) is the second most common type of neurodegenerative disorder; it is characterized by broken motor functions and the buildup of the α-synuclein protein into Lewy bodies. The 2012 study from Luk and colleagues changed how PD pathology is understood, demonstrating the synthetic forms of the pre-fibrils of α-synuclein protein can prompt a complete neurodegenerative cascade in the wild type mice through a mechanism of prion like transmission. This review analyses the current understanding of the structures of the α-synuclein protein, how the protein aggregates and the formation of Lewy bodies. We discuss as well the evidence supporting the prion-like hypothesis of the progression of the disease. We discuss the fibril constructions' dorsal striatum of the mice's dorsal nuclear fibrils, and the nontransgenic mice's dorsal striatum's dorsal nuclear fibrils, and in the fibril constructions' dorsal striatum's nontransgenic mice dorsal Striatum's fibrils dorsal nuclear the dorsal Striatum's nontransgenic mice fibrils, dorsal Striatum, nontransgenic mice. The immuno-therapy. As well, the biomedical guidelines the brain areas, degeneration of brain areas, and the LD-like degeneration of the dorsal Striatum, compartments of the dorsal Striatum's compartments, the compartments'entre eux compartments, the compartments of the compartments of Striatum.