Advances in the Application of Growth Factors in Chronic Diabetic Wounds

Jinhui   Jiang; Peijian Huang; Yi Li; Ying Guan; Qiang Tang

doi:10.54097/wq30hv47

Authors

Jinhui Jiang
Peijian Huang
Yi Li
Ying Guan
Qiang Tang

DOI:

https://doi.org/10.54097/wq30hv47

Keywords:

Chronic Diabetic Wounds, Growth Factors, Wound Healing, Combination Therapy

Abstract

Growth factors are important signal substances that control tissue repair, and they offer new ideas for treating this kind of disease, this paper sorts out the working principles and current uses of common growth factors including epidermal growth factor and vascular endothelial growth factor, it analyzes the main roles of different growth factors in cell increase and blood vessel formation, and also points out the problems of weak stability and short survival time of single growth factor, meanwhile, it sums up the cooperative effects when multiple growth factors are used together, and discusses the application progress of new delivery methods like nanotechnology and 3D bioprinting, at present, related studies still have limitations such as not enough clinical trial data and no confirmed long-term safety, future research needs to explore its working principles more deeply, finish clinical verification and make personalized treatment plans, so as to push the clinical application and standardized use of growth factors in treating chronic diabetic wounds, and help improve the recovery condition of patients.

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