Advances in Biotechnology for α-Glucosidase Inhibitory Research
DOI:
https://doi.org/10.54097/jgt8xa25Keywords:
α-glucosidase inhibitors, diabetes mellitus, microbial fermentation, biosynthesis, bioactive peptides.Abstract
Alpha-Glucosidase inhibitors (AGIs) are effective agents for managing postprandial hyperglycemia in type 2 diabetes mellitus (T2DM). With the increasing demand for safe and natural hypoglycemic compounds, biotechnology-based approaches have become crucial for the discovery and development of novel AGIs. This article reviews recent research progress of biotechnology in the development of natural AGIs from the following aspects. Firstly, the microbial sources of natural AGIs are constantly expanding, with a large number of AGIs reported from medicinal fungi, edible fungi, probiotics, and endophytic fungi in plants. Meanwhile, studies on using fermentation and enzymatic biotransformation to enhance the content and bioactivity of natural AGIs in medicinal plants have achieved significant progress. In addition, advanced technologies such as metabolomic analysis, synthetic biology, and high-throughput targeted screening have been widely applied in natural AGIs research. The integrated application of these biotechnological approaches facilitates the discovery of potent and safe AGIs, promoting their industrial application and potential value in T2DM management.
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