Sucrose Monoester-Mediated Topical Antifungal Delivery: Interface Regulation-Driven Multi-Barrier Penetration Enhancement and Synergistic Potentiation
DOI:
https://doi.org/10.54097/dq5nqv64Keywords:
Sucrose monoesters, non-ionic surfactants, HLB, interface regulation, antifungal drug delivery, synergistic potentiation.Abstract
Topical fungal infections are relatively common, and the problem of drug-resistant strains has been added. SMEs (sucrose monoesters) are naturally occurring non-ionic sugar-based surfactants that exhibit good biocompatibility and can modify the hydrophilic-lipophilic balance (HLB) and aggregation behaviour. They can dissolve or disperse at the interface, and thus are frequently used as topical antifungal agents. Research on the influence of structural composition, HLB modification and preparation purity on the performance of SMEs has been conducted, focusing on the "interface regulation-driven barrier microstructure rearrangement" penetration enhancement mechanism. Applications of SMEs in skin, mucosa and other sites for transungual delivery are discussed, as well as formulation strategies for various delivery platforms, including microemulsions/nanoemulsions, liposomes, SLNs/NLCs, bigels and bioadhesive preparations of azoles, allylamines and polyenes. Potential antifungal synergistic potentiation and safety profiles have also been presented. Finally, the translation bottleneck will be addressed, and in the future, specific structural Design and quantitative mechanistic verification will be further explored.
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