The Fruit in Alleviating Neurological Diseases via the Gut-Brain Axis
DOI:
https://doi.org/10.54097/1caj3s59Keywords:
Fruits, Gut microbiota, SCFA, Neurological disease, Autism spectrum disorder (ASD)Abstract
Fruits, as an important component of a healthy diet, not only contain essential nutrients for daily life, but also contain various bioactive substances, which have beneficial effects on human health. Currently, research on fruit function has focused on fruit and gut microbiota. The gut microbiota affects many important functions of the body through metabolism. At present, the relationship between gut microbiota and brain diseases, metabolic diseases, etc. has become a research focus. In the study of fruits and gut microbiota, researchers have found that it is mainly through regulating the composition of short chain fatty acids (SCFA). It is currently known that disorder of SCFA in the gut is one of the important mechanisms for some diseases. Mental disorders such as depression and autism spectrum disorder (ASD), are all associated with SCFA. Meanwhile, with the study of fruit and gut microbiota, it may be possible to prevent or even alleviate some neurological diseases by modifying the intake of fruits. In recent years, gut microbiota, ASD, and fruit intake have become important issue, and there are many related literature but a lack of systematic review. This paper analyzed the impact of different types of fruits on gut microbiota, as well as the disruption of SCFA caused by changes in gut microbiota in patients with neurological diseases. It also demonstrates that some bioactive substances can regulate SCFA, providing ideas for the treatment and alleviation of some diseases.
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References
Davis, C., et al., Definition of the Mediterranean Diet; a Literature Review. Nutrients, 2015. 7(11): p. 9139-53.
Wang, J., et al., The Jiangnan diet, a healthy diet pattern for Chinese. J Diabetes, 2020. 12(5): p. 365-371.
Trichopoulou, A., A. Naska, and E. Vasilopoulou, Guidelines for the intake of vegetables and fruit: the Mediterranean approach. Int J Vitam Nutr Res, 2001. 71(3): p. 149-53.
Lee, S.H., et al., Adults Meeting Fruit and Vegetable Intake Recommendations - United States, 2019. MMWR Morb Mortal Wkly Rep, 2022. 71(1): p. 1-9.
Liu, R.H., Health-promoting components of fruits and vegetables in the diet. Adv Nutr, 2013. 4(3): p. 384s-92s.
Slavin, J.L. and B. Lloyd, Health benefits of fruits and vegetables. Adv Nutr, 2012. 3(4): p. 506-16.
Adak, A. and M.R. Khan, An insight into gut microbiota and its functionalities. Cell Mol Life Sci, 2019. 76(3): p. 473-493.
Jiang, Z., et al., Dietary fruit and vegetable intake, gut microbiota, and type 2 diabetes: results from two large human cohort studies. BMC Med, 2020. 18(1): p. 371.
Katsirma, Z., et al., Fruits and their impact on the gut microbiota, gut motility and constipation. Food Funct, 2021. 12(19): p. 8850-8866.
Wang, R., et al., Noni (Morinda citrifolia L.) fruit phenolic extract supplementation ameliorates NAFLD by modulating insulin resistance, oxidative stress, inflammation, liver metabolism and gut microbiota. Food Res Int, 2022. 160: p. 111732.
Giampieri, F., et al., Strawberry as a health promoter: an evidence based review. Food Funct, 2015. 6(5): p. 1386-98.
Salazar-López, N.J., et al., Avocado fruit and by-products as potential sources of bioactive compounds. Food Res Int, 2020. 138(Pt A): p. 109774.
Vučić, V., et al., Composition and Potential Health Benefits of Pomegranate: A Review. Curr Pharm Des, 2019. 25(16): p. 1817-1827.
Pereira, A. and M. Maraschin, Banana (Musa spp) from peel to pulp: ethnopharmacology, source of bioactive compounds and its relevance for human health. J Ethnopharmacol, 2015. 160: p. 149-63.
Cladis, D.P., et al., Blueberry polyphenols alter gut microbiota & phenolic metabolism in rats. Food Funct, 2021. 12(6): p. 2442-2456.
Koutsos, A., K.M. Tuohy, and J.A. Lovegrove, Apples and cardiovascular health--is the gut microbiota a core consideration? Nutrients, 2015. 7(6): p. 3959-98.
Dou, Z., et al., In vitro digestion of the whole blackberry fruit: bioaccessibility, bioactive variation of active ingredients and impacts on human gut microbiota. Food Chem, 2022. 370: p. 131001.
Anhê, F.F., et al., Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice. Gut, 2019. 68(3): p. 453-464.
Song, H., et al., Pomegranate fruit pulp polyphenols reduce diet-induced obesity with modulation of gut microbiota in mice. J Sci Food Agric, 2022. 102(5): p. 1968-1977.
Singer-Englar, T., G. Barlow, and R. Mathur, Obesity, diabetes, and the gut microbiome: an updated review. Expert Rev Gastroenterol Hepatol, 2019. 13(1): p. 3-15.
Shin, N.R., T.W. Whon, and J.W. Bae, Proteobacteria: microbial signature of dysbiosis in gut microbiota. Trends Biotechnol, 2015. 33(9): p. 496-503.
Tian, L., et al., Metabolism of anthocyanins and consequent effects on the gut microbiota. Crit Rev Food Sci Nutr, 2019. 59(6): p. 982-991.
Bai, Y., et al., Longan pulp polysaccharides regulate gut microbiota and metabolites to protect intestinal epithelial barrier. Food Chem, 2023. 422: p. 136225.
Wang, L., et al., Polysaccharide from Rosa roxburghii Tratt Fruit Attenuates Hyperglycemia and Hyperlipidemia and Regulates Colon Microbiota in Diabetic db/db Mice. J Agric Food Chem, 2020. 68(1): p. 147-159.
Sangkuanun, T., et al., Oligosaccharides derived from dragon fruit modulate gut microbiota, reduce oxidative stress and stimulate toll-pathway related gene expression in freshwater crustacean Daphnia magna. Fish Shellfish Immunol, 2020. 103: p. 126-134.
Pansai, N., et al., Effects of dragon fruit oligosaccharides on immunity, gut microbiome, and their metabolites in healthy adults - A randomized double-blind placebo controlled study. Food Res Int, 2023. 167: p. 112657.
Xiang, J.Y., et al., Litchi chinensis seed prevents obesity and modulates the gut microbiota and mycobiota compositions in high-fat diet-induced obese zebrafish. Food Funct, 2022. 13(5): p. 2832-2845.
Istas, G., et al., Effects of aronia berry (poly)phenols on vascular function and gut microbiota: a double-blind randomized controlled trial in adult men. Am J Clin Nutr, 2019. 110(2): p. 316-329.
Blaak, E.E., et al., Short chain fatty acids in human gut and metabolic health. Benef Microbes, 2020. 11(5): p. 411-455.
Zhao, L., et al., Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science, 2018. 359(6380): p. 1151-1156.
Liu, L., et al., Gut microbiota and butyrate contribute to nonalcoholic fatty liver disease in premenopause due to estrogen deficiency. PLoS One, 2022. 17(2): p. e0262855.
Bartolomaeus, H., et al., Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage. Circulation, 2019. 139(11): p. 1407-1421.
Zhang, S., H. Wang, and M.J. Zhu, A sensitive GC/MS detection method for analyzing microbial metabolites short chain fatty acids in fecal and serum samples. Talanta, 2019. 196: p. 249-254.
Overall, J., et al., Metabolic Effects of Berries with Structurally Diverse Anthocyanins. Int J Mol Sci, 2017. 18(2).
Morrison, D.J. and T. Preston, Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism. Gut Microbes, 2016. 7(3): p. 189-200.
Campos-Perez, W. and E. Martinez-Lopez, Effects of short chain fatty acids on metabolic and inflammatory processes in human health. Biochim Biophys Acta Mol Cell Biol Lipids, 2021. 1866(5): p. 158900.
Primec, M., et al., Clinical intervention using Bifidobacterium strains in celiac disease children reveals novel microbial modulators of TNF-α and short-chain fatty acids. Clin Nutr, 2019. 38(3): p. 1373-1381.
Nyangale, E.P., D.S. Mottram, and G.R. Gibson, Gut microbial activity, implications for health and disease: the potential role of metabolite analysis. J Proteome Res, 2012. 11(12): p. 5573-85.
Zhong, M., et al., Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. Food Funct, 2022. 13(13): p. 7287-7301.
Lei, Y., et al., Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration. Microbiome, 2021. 9(1): p. 115.
Wang, M.X., et al., Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production. Pharmacol Res, 2020. 159: p. 104978.
Liu, S., et al., Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder. Sci Rep, 2019. 9(1): p. 287.
Iglesias-Vázquez, L., et al., Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Nutrients, 2020. 12(3).
Settanni, C.R., et al., Gastrointestinal involvement of autism spectrum disorder: focus on gut microbiota. Expert Rev Gastroenterol Hepatol, 2021. 15(6): p. 599-622.
Adams, J.B., et al., Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity. BMC Gastroenterol, 2011. 11: p. 22.
Wang, Y., et al., Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder. Pharmacol Res, 2020. 157: p. 104784.
Rautava, S., et al., Microbial contact during pregnancy, intestinal colonization and human disease. Nat Rev Gastroenterol Hepatol, 2012. 9(10): p. 565-76.
Liu, J., et al., Alteration of Gut Microbiota: New Strategy for Treating Autism Spectrum Disorder. Front Cell Dev Biol, 2022. 10: p. 792490.
Amalia, R., et al., Mangrove fruit (Bruguiera gymnorhiza) increases circulating GLP-1 and PYY, modulates lipid profiles, and reduces systemic inflammation by improving SCFA levels in obese wistar rats. Heliyon, 2022. 8(10): p. e10887.
Ju, Y., et al., Passion fruit peel and its zymolyte enhance gut function in Sanhuang broilers by improving antioxidation and short-chain fatty acids and decreasing inflammatory cytokines. Poult Sci, 2023. 102(6): p. 102672.
Chen, C., et al., In vitro fermentation of mulberry fruit polysaccharides by human fecal inocula and impact on microbiota. Food Funct, 2016. 7(11): p. 4637-4643.
Guergoletto, K.B., et al., In vitro fermentation of juçara pulp (Euterpe edulis) by human colonic microbiota. Food Chem, 2016. 196: p. 251-8.
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