Study on pathologic mechanism and treatment of hypertension
DOI:
https://doi.org/10.54097/n7cp3y05Keywords:
Hypertension; Antihypertensive drugs; Complications; Stroke.Abstract
Hypertension is a cardinal contributor to the global burden of disease due to its widespread prevalence and its insidious ability to instigate life-threatening complications such as stroke, cardiac failure, and renal injury disorders. This discourse reviewed the key drivers of hypertension pathogenesis, emphasizing the role of the renal system, particularly the interplay of angiotensin II and renal impairment. Moreover, hypertension's complex and multivalent management strategies were overviewed, illustrating the salience of lifestyle modifications, a panoply of pharmacological interventions, synergistic combination therapies, and the innovative approach of personalized medicine. Nevertheless, challenges such as medication adherence and balancing side effects remain, alongside the requirement for persistent medical oversight reflective of hypertension’s chronic nature. As lethal complications ink the finality of hypertension’s narrative, prompt identification and treatment are paramount. This comprehensive account concludes with an urge to further dissect this intricate condition and refine management strategies, propelling us towards a future with more efficacious hypertension control and diminished complication rates.
Downloads
References
John Elflein , Hypertension and high blood pressure, 2023, 1988-2018
Oparil, Suzanne, et al. “Pathogenesis of Hypertension.” Annals of Internal Medicine, no. 9, American College of Physicians, Nov. 2003, p. 761.
Staessen, Jan A., et al. “Essential Hypertension.” The Lancet, no. 9369, Elsevier BV, May 2003, pp. 1629–41.
Humphrey, Jay D. “Mechanisms of Vascular Remodeling in Hypertension.” American journal of hypertension vol. 34,5 (2021): 432-441.
Seravalle, Gino et al. “Role of the sympathetic nervous system in hypertension and hypertension-related cardiovascular disease.” High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension vol. 21,2 (2014): 89-105.
Procopciuc, Lucia et al. “Essential arterial hypertension and polymorphism of angiotensinogen M235T gene.” Journal of cellular and molecular medicine vol. 6,2 (2002): 245-50.
Touyz, Rhian M. “Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II.” Current opinion in nephrology and hypertension vol. 14,2 (2005): 125-31.
Guan, Z et al. “Purinoceptors, renal microvascular function and hypertension.” Physiological research vol. 69,3 (2020): 353-369.
Lackland, Daniel T., et al. “Implications of Recent Clinical Trials and Hypertension Guidelines on Stroke and Future Cerebrovascular Research.” Stroke, no. 3, Ovid Technologies (Wolters Kluwer Health), Mar. 2018, pp. 772–79.
Di Palo, Katherine E, and Nicholas J Barone. “Hypertension and Heart Failure: Prevention, Targets, and Treatment.” Heart failure clinics vol. 16,1 (2020): 99-106.
Mennuni, S et al. “Hypertension and kidneys: unraveling complex molecular mechanisms underlying hypertensive renal damage.” Journal of human hypertension vol. 28,2 (2014): 74-9.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
